Growth optimization of single-phase novel colloidal perovskite Cs3Bi2I9 nanocrystals and Cs3Bi2I9@SiO2 coreshell nanocomposites for bio-medical application
Growth optimization of single-phase novel colloidal perovskite Cs3Bi2I9 nanocrystals and Cs3Bi2I9@SiO2 coreshell nanocomposites for bio-medical application
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用于生物医学应用的单相新型胶体钙钛矿Cs3Bi2I9纳米晶体和Cs3Bi2I9@SiO2核壳纳米复合材料的生长优化
DOI：
10.1039/d2bm00773h
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发表时间：
2022
影响因子：
6.6
通讯作者：
Shkir Mohd.
中科院分区：
文献类型：
--
作者：
Vedi Santhana;Dheivasigamani Thangaraju;Selvam Govarthini Seerangan;Kawakami Takashi;Rajeswaran Narmadha;Rajendran Selvakumar;Muthukaruppan Alagar;AlFaify S.;Shkir Mohd.
近年来，无铅卤化物钙钛矿作为具有比传统半导体材料更独特特性的可行材料而受到关注。选择无铅的Cs3 Bi 2 I9胶体钙钛矿结构，以消除其单相合成的困难，并将该材料应用于生物成像应用。采用原位注入法在Cs3 Bi 2 I9钙钛矿复合材料表面包覆一层SiO2，以提高复合材料在水介质中的稳定性和生物相容性。采用不同的合成条件和不同的实验参数，成功地开发并优化了单相新型Cs3 Bi 2 I9胶体钙钛矿的合成方法。表征研究，包括X射线衍射和透射电子显微镜，确认Cs3 Bi 2 I9晶体的六方结构和它们的立方形态。在不同的激发波长下，纯钙钛矿和复合钙钛矿在红色区域中的宽发射峰被捕获，并使用紫外-可见分光光度计观察到。采用倒置荧光显微镜在蓝色和绿色激发下对掺入L929细胞的Cs3Bi2I9@SiO2复合材料进行生物成像。从生物成像研究中获得的结果表明，Cs3Bi2I9@SiO2纳米复合材料进入细胞场，并在激发下显示出发射。通过MTT细胞毒性实验证明了合成的Cs3Bi2I9@SiO2复合材料在L929小鼠成纤维细胞中的无毒行为，显示出较好的细胞相容性。
Lead-free halide perovskites have gained attention in recent years as viable materials with more distinctive characteristics than conventional semiconductor materials. Lead-free Cs3Bi2I9 colloidal perovskite nanocrystal is chosen to eliminate its single-phase synthesis difficulty and implement the material in bioimaging applications. Nanostructured Cs3Bi2I9 perovskite composites were coated with a thin coating of SiO2 by an in situ tetraethyl orthosilicate/(3-aminopropyl)trimethoxysilane injection growth method to enhance their stability in aqueous medium and biocompatibility. Single-phase novel Cs3Bi2I9 colloidal perovskite nanocrystal synthesis was successfully developed and optimized by adopting different synthetic conditions with varied experimental parameters. Characterization studies, including X-ray diffractometry and transmission electron microscopy, confirm the hexagonal structure of Cs3Bi2I9 crystals and their cubic morphology. A broad emission peak in the red region was captured for pure and composite perovskite under different excitation wavelengths and was observed using a UV-visible spectrophotometer. Bioimaging of Cs3Bi2I9@SiO2 composites incorporated with L929 cells was conducted using an inverted fluorescence microscope under blue and green excitation. The results obtained from bioimaging studies indicated that the Cs3Bi2I9@SiO2 nanocomposites entered the cell field and exhibited an emission under excitation. The non-toxic behavior of the synthesized Cs3Bi2I9@SiO2 composites was demonstrated using MTT cytotoxicity assay in L929 fibroblast mouse cells, showing better cell compatibility.