Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors
Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors
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新型脲酶抑制剂二硫代双乙酰胺的合成及生物学评价
DOI：
10.1002/cmdc.202100618
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发表时间：
2022
期刊：
影响因子：
3.4
通讯作者：
Hai-Liang Zhu
中科院分区：
文献类型：
--
作者：
Mei-Ling Liu;Wei-Yi Li;Hai-Lian Fang;Ya-Xi Ye;Su-Ya Li;Wan-Qing Song;Zhu-Ping Xiao;Hui Ouyang;Hai-Liang Zhu
设计并合成了38个含N-芳基乙酰胺的二硫醚类化合物，旨在开发新型脲酶抑制剂。生物学评价显示，一些合成化合物对两种细胞自由基都表现出很强的抑制效力，
Thirty‐eight disulfides containing N‐arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell‐fre