Early-Pregnancy Cytokines in Mothers to Children Developing Multiple, Persistent Islet Autoantibodies, Type 1 Diabetes, or Both Before 7 Years of Age
Early-Pregnancy Cytokines in Mothers to Children Developing Multiple, Persistent Islet Autoantibodies, Type 1 Diabetes, or Both Before 7 Years of Age
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DOI：
10.1111/j.1600-0897.2011.01057.x
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发表时间：
2011-12-01
影响因子：
3.6
通讯作者：
Lernmark, Ake
中科院分区：
文献类型：
--
作者：
Lindehammer, Sabina Resic;Fex, Malin;Lernmark, Ake
问题妊娠早期血清细胞因子水平升高可能会增加后代患 1 型糖尿病的风险。研究方法对 7 岁之前患有胰岛自身免疫、1 型糖尿病或两者兼有的儿童的非糖尿病指数母亲 (n = 48) 的妊娠早期（妊娠 10 至 16 周之间）血清样本进行 IFN-γ、IL-10、IL-12 分析。 IL-13、IL-1β、IL-2、IL-4、IL-5、CXCL8 和 TNF。对照母亲 (n = 93) 的年龄、采样日期和 HLA-DQ 基因型进行匹配。结果 IFN-gamma (P = 0.02) 和 IL-1 beta (P = 0.04) 在指数母亲中升高。除 IL-4 外，所有细胞因子均高度相关 (P < 0.0001)。妊娠早期的 IFN-gamma [OR 1.39 (1.04, 1.85), P = 0.026] 和可能的 IL-2 [OR 1.21 (0.99, 1.48), P = 0.057] 与后代 7 岁之前罹患多种持续性胰岛自身抗体、1 型糖尿病或两者的风险增加相关。然而，当根据分娩时的孕周长度和产次进行调整后，IL-2 的统计显着性在逻辑回归中消失了。 结论 妊娠早期 Th1 细胞因子水平增加可能会导致后代患胰岛自身免疫、1 型糖尿病或两者的风险增加。
ProblemIncreased levels of serum cytokines in early pregnancy may increase the risk of type 1 diabetes in the offspring.Method of studyEarly-pregnancy (between 10 and 16 gestational weeks) serum samples from non-diabetic index mothers (n = 48) of children who developed islet autoimmunity, type 1 diabetes, or both before 7 years of age were analyzed for IFN-gamma, IL-10, IL-12, IL-13, IL-1 beta, IL-2, IL-4, IL-5, CXCL8, and TNF. Control mothers (n = 93) were matched for age, sampling date, and HLA-DQ genotypes.ResultsIFN-gamma (P = 0.02) and IL-1 beta (P = 0.04) were elevated in the index mothers. All cytokines except IL-4 were highly correlated (P < 0.0001). IFN-gamma [OR 1.39 (1.04, 1.85), P = 0.026] and possibly IL-2 [OR 1.21 (0.99, 1.48), P = 0.057] in early pregnancy were associated with an increased risk of multiple, persistent islet autoantibodies, type 1 diabetes, or both before 7 years of age in the offspring. However, the statistical significance for IL-2 was lost in the logistic regression when adjusted for gestational length at delivery and parity.ConclusionIncreased Th1 cytokine levels during early pregnancy might contribute to an increased risk of islet autoimmunity, type 1 diabetes, or both in the offspring.