Relaxin secretion in the rhesus monkey.
Relaxin secretion in the rhesus monkey.
复制标题
恒河猴的松弛素分泌。
DOI：
10.1095/biolreprod24.3.565
复制
发表时间：
1981
影响因子：
3.6
通讯作者：
Fritz,G
中科院分区：
文献类型：
--
作者：
Weiss,G;Steinetz,BG;Dierschke,DJ;Fritz,G
用猪松弛素放免法测定了55只成年恒河猴的血清样品。这一结果被报道为猪松弛素免疫反应的等价物。在整个月经周期中，5只完整的雄性猴子或6只骑自行车的雌性猴子在整个月经周期中每隔2至3天采样一次，血清中没有检测到松弛素。在怀孕第三周后，从怀孕猴子的血清中检测到松弛素。从这一点开始，它在整个怀孕期间都存在于血清中。在三只去卵巢妊娠猴的血清中未检测到松弛素。这些数据表明，卵巢是猴子循环松弛素的主要来源。由于在卵巢分泌少量黄体酮的时候可以检测到松弛素，这表明黄体分泌这些激素的关系很小。在女性中，从怀孕期间错过月经的时候起，血清中就存在松弛素。在松弛素和孕酮的顺序分泌方面，猴子和女性在怀孕早期的黄体功能上有很大的不同。
Serum samples from 55 mature rhesus monkeys were assayed by a porcine relaxin RIA. The results were reported as immunoreactive equivalents of porcine relaxin. No relaxin was detected in serum from five intact male monkeys or from six cycling females sampled every 2 to 3 days during the entire menstrual cycle. Relaxin was detected in sera from pregnant monkeys after the third week of gestation. From this point it was present in serum throughout pregnancy. Relaxin was undetectable in the sera of three ovariectomized pregnant monkeys.These data suggest that the ovary is the major source of circulating relaxin in monkeys. Since relaxin is detectable at a time when the ovary is secreting little progesterone, this suggests little relationship of luteal secretion of these hormones. In women, relaxin is present in serum from the time of the missed menses in pregnancy. There are major differences in luteal function in early pregnancy between monkeys and women with regard to sequential secretion profiles of relaxin and progesterone.