OSSEOINTEGRATION AND ITS EXPERIMENTAL BACKGROUND
OSSEOINTEGRATION AND ITS EXPERIMENTAL BACKGROUND
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DOI：
10.1016/s0022-3913(83)80101-2
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发表时间：
1983-01-01
影响因子：
4.6
通讯作者：
BRANEMARK, PI
中科院分区：
文献类型：
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作者：
BRANEMARK, PI
Per-Ingvar Brinemark，医学博士，博士*G6teborg大学和瑞典盖特堡应用生物技术研究所在临床牙科中的整合取决于对硬组织和软组织的愈合和修复能力的理解。它的目标是对牙根类似物的放置产生可预测的组织反应。这样的响应必须是高度差异化的响应，并且根据功能需求：NDS进行组织。自1952年以来，我们一直在隆德大学生命显微镜实验室和格特堡大学实验生物学实验室研究组织集成假体的概念。我们在这项研究中的合作者包括来自医学和牙科学院、各种研究机构和技术部门的代表。基本目标是确定临床植入手术的限制，使骨和骨髓组织能够完全愈合并保持原状，而不是像低分化疤痕组织那样愈合，并产生不可预测的后遗症。这些研究包括对不同动物不同部位的组织损伤和修复的分析，特别是对微血管结构和功能的分析。特别强调通过一系列不同的方法分析血液的血管内流变学造成的干扰。本文的目的是简要回顾导致骨整合临床应用的各种研究。
Per-Ingvar Brinemark, MD, Ph. D.* University of G6teborg and Institute for Applied Biotechnology, Gateborg, Sweden0 sseointegration in clinical dentistry depends on an understanding o: f the healing and reparative capacities of hard and soft tissues. Its objective is a predictable tissue response to the placement of tooth root analogues. Such a response must be a highly differentiated one, and one that becomes organized according to functional dema: nds. Since 1952, we have studied the concept of tissue4ntegrated prostheses at the Laboratory of Vital Microscopy at the University of Lund, and subsequently at the Laboratory for Experimental Biology at the University of GGteborg. Our collaborators in this research have included representatives from medical and dental faculties, various research institutes, and departments of technology. The basic aim has been to define limits for clinical implantation procedures that will allow bone and marrow tissues to heal fully and remain as such, rather than heal as a low differentiated scar tissue with unpredictable sequelae. The studies involved analyses of tissue injury and repair in diverse sites in different animals, with particular reference to microvascular structure and function. Special emphasis was placed on analyzing the disturbances caused in the intravascular rhelology of blood by means of a series of different methodological approaches. The objective of this article is a brief review of the various investigations that have led to the clinical application of osseointegration.