Effector translocation by the Legionella Dot/Icm type IV secretion system.
Effector translocation by the Legionella Dot/Icm type IV secretion system.
复制标题
军团菌 Dot/Icm IV 型分泌系统的效应器易位。
DOI：
10.1007/82_2013_345
复制
发表时间：
2013
影响因子：
--
通讯作者：
Luo,Zhao-Qing
中科院分区：
文献类型：
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作者：
Qiu,Jiazhang;Luo,Zhao-Qing
嗜肺军团菌是一种导致军团病的机会性病原体。这种细菌通过绕过吞噬细胞的杀菌活性在吞噬细胞内生存和复制。 L.的细胞内复制嗜肺军团菌需要由大约 27 种蛋白质组成的 Dot/Icm IV 型分泌系统，该系统可能穿过细菌和吞噬体膜。宿主杀伤能力的扰动很大程度上是由通过 Dot/Icm 转运蛋白注射到宿主细胞中的蛋白质底物的集体功能介导的。 Dot/Icm 的正确蛋白质易位由许多因素决定，包括易位器可识别的信号、可能促进底物正确折叠的分子伴侣以及决定底物丰度和时间转移的转录调控和蛋白质稳定性。尽管已鉴定出大量 Dot/Icm 底物，但了解易位的研究仍在进行中。在这里，我们总结了我们对决定 Dot/Icm 转运蛋白易位活性的因素的理解的最新进展。
Legionella pneumophilais an opportunistic pathogen responsible for Legionnaires’ disease. This bacterium survives and replicates within phagocytes by bypassing their bactericidal activity. Intracellular replication ofL. pneumophilarequires the Dot/Icm type IV secretion system made of approximately 27 proteins that presumably traverses the bacterial and phagosomal membranes. The perturbation of the host killing ability largely is mediated by the collective functions of the protein substrates injected into host cells via the Dot/Icm transporter. Proper protein translocation by Dot/Icm is determined by a number of factors, including signals recognizable by the translocator, chaperones that may facilitate the proper folding of substrates and transcriptional regulation and protein stability that determine the abundance and temporal transfer of the substrates. Although a large number of Dot/Icm substrates have been identified, investigation to understand the translocation is ongoing. Here we summarized the recent advancements in our understanding of the factors that determine the protein translocation activity of the Dot/Icm transporter.