Increased risk of pregnancy-induced hypertension in young recipients of donated oocytes
Increased risk of pregnancy-induced hypertension in young recipients of donated oocytes
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DOI：
10.1016/j.fertnstert.2006.08.105
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发表时间：
2007-04-01
影响因子：
6.7
通讯作者：
Noyes, Nicole
中科院分区：
文献类型：
--
作者：
Keegan, Debbra A.;Krey, Lewis C.;Noyes, Nicole
目的：评估40岁接受卵母细胞捐赠（OD）的患者选择产科结局的比率，并将其与相似年龄的IVF患者进行比较。设计：回顾性匿名问卷研究。地点：大学试管婴儿中心。患者：199例OD接受者和488例IVF患者经历了活产结局=年。干预(S)：体外受精周期或体外受精周期。主要结局指标：有效率、妊娠结局、并发症。结果：有效率为60%。OD受体的妊娠高血压（PIH）发生率明显高于体外受精组。OD = 40年（26%），体外受精>= 40年（14%），体外受精患者= 40年（25%），体外受精= 40年（19%）和较低的早产率（16%）反映了这种差异。OD = 40年的单胎剖宫产率为50%，双胎剖宫产率为78%，分别为75%和84%。结论：与体外受精患者相比，接受药物注射的患者发生不良产科结局的风险更高。年轻的口服药物受体报告的PIH发生率最高，值得进一步调查早期卵巢功能丧失与PIH之间的关系。
Objective: To assess the rates of select obstetric outcomes in oocyte donation (OD) recipients aged = 40 years and compare them to similarly aged IVF patients.Design: Retrospective anonymous questionnaire study.Setting: University-based IVF center.Patient(s): Live-birth outcome was experienced by 199 OD recipients and 488 IVF patients = years.Intervention(S): The OD or IVF cycles.Main Outcome Measure(s): Response rate, pregnancy outcome, and complications.Result(s): Response rate was 60%. The OD recipients had significantly higher rates of pregnancy-induced hypertension (PIH) than their IVF counterparts. The OD = 40 years (26%), IVF >= 40 years (14%), and IVF patients = 40 years (25%), and IVF = 40 years (19%) and a lower preterm delivery rate (16%) reflected this difference. The cesarean section rates were 50% for singleton and 78% or twin deliveries in the OD patients = 40 years, the rates were 75% and 84%, respectively.Conclusion(S): The OD recipients are at higher risk for untoward obstetric outcomes than their IVF counterparts. Young OD recipients reported the highest rate of PIH, warranting further investigation into an association between early loss of ovarian function and PIH.