SELECTION FOR AND AGAINST INSECTICIDE RESISTANCE AND POSSIBLE METHODS OF INHIBITING EVOLUTION OF RESISTANCE IN MOSQUITOS
SELECTION FOR AND AGAINST INSECTICIDE RESISTANCE AND POSSIBLE METHODS OF INHIBITING EVOLUTION OF RESISTANCE IN MOSQUITOS
复制标题
DOI：
10.1111/j.1365-2311.1978.tb00928.x
复制
发表时间：
1978-01-01
影响因子：
2.2
通讯作者：
WOOD, RJ
中科院分区：
文献类型：
--
作者：
CURTIS, CF;COOK, LM;WOOD, RJ
根据库氏按蚊和史氏按蚊野生种群杀虫剂抗药性建立速率的数据，计算了产生这些进化速率所需的选择系数。阻力实际上可能是显性的、隐性的或中间的。在A. culicifacies对DDT抗性的情况下，抗性个体的适合度是1.28-1.51倍。就是易感者。参照撤消喷雾时发生的易感性回复来检查数据。计算抗性选择系数（产生观察到的回复率所需的）。对于 A. culicifacies 和 DDT，这些系数与易感基因的初始频率成反比。选择系数用于评估通过在网格图案的交替区域喷洒不同杀虫剂和/或定期释放易感雄性来抑制抗性进化的可行性。如果各部门之间的移民比例为15-30%，网格系统将降低阻力的演变速度，但为了防止阻力累积到高水平，也需要定期释放。如果抗性在田间实际上是隐性的，则这些释放不需要频繁（大约每年 1 个月）。
From data on the rate of build-up of insecticide resistance in wild populations of Anopheles culicifacies and A. stephensi, calculations were made of the coefficients of selection required to produce these rates of evolution. Resistances might be effectively dominant, recessive or intermediate. In the case of DDT resistance in A. culicifacies the fitness of resistant individuals was 1.28-1.51.times. that of susceptibles. Data were examined with reference to the reversions towards susceptibility which occurred when spraying was withdrawn. The coefficients of selection against resistance, (required to produce observed rates of reversion) were calculated. In the case of A. culicifacies and DDT these coefficients were inversely related to the initial frequency of the susceptibility gene. The coefficients of selection were used to assess the feasibility of inhibiting the evolution of resistance by spraying different insecticides in the alternate sectors of a grid pattern and/or periodically releasing susceptible males. If the proportion of migrants from sector to sector were 15-30%, a grid system would reduce the rate of evolution of resistance, but to prevent resistance from building up to high levels periodic releases are also required. These releases need not be frequent (approximately during 1 mo. each year) if resistance is effectively recessive in the field.