High frequency of histocompatibility antigens HLA-DR3 and DR4 in herpes gestations.
High frequency of histocompatibility antigens HLA-DR3 and DR4 in herpes gestations.
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妊娠疱疹中组织相容性抗原 HLA-DR3 和 DR4 的出现频率较高。
DOI：
10.1172/jci110287
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Gilliam,JN
中科院分区：
文献类型：
--
作者：
Shornick,JK;Stastny,P;Gilliam,JN
妊娠期疱疹是一种罕见的自身免疫性大疱性疾病，发生于妊娠期或产褥期，其特征是皮肤基底膜区的透明层内有补体（偶见免疫球蛋白）沉积。我们研究了23例有HG病史的患者，其中20例在疾病的活动期有典型的免疫荧光结果。HLA分型结果显示：61%的患者（对照组22%，Pc <0.005）为HLA-DR 3型，43%的患者（对照组3%，Pc <0.00001）为DR 3 + DR 4型。本研究最引人注目的发现是，HG的最大风险与同时存在两种特定的组织相容性白细胞抗原（HLA）-DR抗原有关。
Herpes gestationis (HG) is a rare, autoimmune, vesiculobullous disease of pregnancy or the puerperium characterized by the deposition of complement (and occasionally immunoglobulin) within the lamina lucida of the cutaneous basement membrane zone. We have studied 23 patients with a history of HG, 20 of whom had typical immunofluorescence findings during the active phase of their disease. HLA typing showed HLA-DR3 in 61% of patients (controls 22%, Pc less than 0.005) and the combination of DR3, DR4 in 43% (controls 3%, Pc less than 0.00001). The most striking finding of this study was that the greatest risk of HG is associated with the concurrent presence of two specific histocompatibility leukocyte antigen (HLA)-DR antigens.