Responses of neurons of the cat central cervical nucleus to natural neck and vestibular stimulation.
Responses of neurons of the cat central cervical nucleus to natural neck and vestibular stimulation.
复制标题
猫中央颈核神经元对自然颈部和前庭刺激的反应。
DOI：
10.1152/jn.1996.76.4.2786
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Wilson,VJ
中科院分区：
文献类型：
--
作者：
Thomson,DB;Isu,N;Wilson,VJ
1.已知中央颈核（CCN）接收颈部和前庭输入并投射到对侧小脑和前庭核。为了研究CCN中细胞对颈部和前庭输入的处理，我们研究了它们对正弦颈部旋转和去大脑瘫痪猫在垂直平面上的全身倾斜的反应。CCN神经元通过放置在对侧网状体中或附近的电极的逆向刺激来识别。2.对于每个神经元，我们首先确定颈部旋转的首选方向（响应向量方向），然后研究神经元在0.05-1 Hz接近该方向的平面内旋转的动力学。3.颈部旋转的CCN神经元的反应类似于先前研究的颈梭初级传入的动力学和非线性反应的不同幅度的刺激。它们也类似于在类似的制备中研究的Deiters神经元的颈部反应。4.三分之二的CCN神经元的活动也受到自然前庭刺激的调节。前庭反应的方向和动力学特征与颈部反应相同。耳石输入主要来源于对侧的垂直管，没有证据表明耳石输入。颈部和前庭输入总是对立的，但前庭反应的增益低于颈部反应在所有频率的研究。5.颈部和前庭输入之间的相互作用的定量方面可以预期的准备和刺激参数的类型而变化，其功能意义仍有待研究。
1. The central cervical nucleus (CCN) is known to receive neck and vestibular input and to project to the contralateral cerebellum and vestibular nuclei. To investigate the processing of neck and vestibular input by cells in the CCN, we studied their responses to sinusoidal neck rotation and to whole-body tilt in vertical planes in decerebrate, paralyzed cats. CCN neurons were identified by antidromic stimulation with electrodes placed in or near the contralateral restiform body. 2. For every neuron, we first identified the preferred direction of neck rotation (response vector orientation), then studied the neuron's dynamics with rotations in a plane close to this direction at 0.05-1 Hz. 3. Responses of CCN neurons to neck rotation resembled those of previously studied neck spindle primary afferents in terms of their dynamics and nonlinear responses to stimuli of differing amplitudes. They also resembled the neck responses of Deiters' neurons studied in similar preparations. 4. The activity of two-thirds of CCN neurons also was modulated by natural vestibular stimulation. Orientation and dynamics of vestibular responses were characterized in the same way as neck responses. Labyrinthine input originated predominantly from the contralateral vertical canals, and there was no evidence of otolith input. Neck and vestibular inputs were always antagonistic, but the gain of the vestibular response was lower than that of the neck response at all frequencies studied. 5. The quantitative aspects of the interaction between neck and vestibular inputs can be expected to vary with the type of preparation and with stimulus parameters, and its functional significance remains to be investigated.