Blood pressure response to strength training may be influenced by angiotensinogen A-20C and angiotensin II type I receptor A1166C genotypes in older men and women.
Blood pressure response to strength training may be influenced by angiotensinogen A-20C and angiotensin II type I receptor A1166C genotypes in older men and women.
复制标题
老年男性和女性对力量训练的血压反应可能受到血管紧张素原 A-20C 和血管紧张素 II I 型受体 A1166C 基因型的影响。
DOI：
10.1111/j.1532-5415.2005.53104.x
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发表时间：
2005
影响因子：
6.3
通讯作者：
Hurley,BenF
中科院分区：
文献类型：
--
作者：
Delmonico,MatthewJ;Ferrell,RobertE;Meerasahib,Anish;Martel,GregF;Roth,StephenM;Kostek,MatthewC;Hurley,BenF
目的：探讨血管紧张素原（AGT） A-20C、m235t和血管紧张素II 1型受体（AGTR1） A1166C基因型对老年男女力量训练（ST）后静息血压（BP）反应的影响。设计：回顾性基因分型的前瞻性干预研究。单位：马里兰大学运动生理学实验室。参与者：70名久坐、健康的老年男性（n=34）和女性（n=36）。干预：大约23周的ST，每周进行3天。测量方法：分别在ST前和ST后6次测量每位受试者的静息血压。从每个受试者的基因组脱氧核糖核酸中回顾性地进行AGT和AGTR1基因分型。结果：AGT A - 20c位点C等位基因携带者的收缩压降低（122±1 ~ 116±2 mmHg，P< 0.05），显著高于A纯合子的收缩压降低（126±1 ~ 123±1 mmHg，P< 0.05）。在AGTR1 A1166C位点，C‐等位基因携带者的舒张压下降幅度（76±1 ~ 70±2 mmHg，P< 0.05）大于a‐等位基因携带者的舒张压下降幅度（75±1 ~ 72±1 mmHg，P< 0.05）。结论：AGT a - 20c和AGTR1 A1166C基因型可能影响静息血压对ST的反应，这两个基因座上的C‐等位基因携带者在ST反应中降低静息血压的程度大于a纯合子。
Objectives:To determine the influence of angiotensinogen (AGT) A–20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women.Design:Prospective intervention study with retrospective genotyping.Setting:University of Maryland Exercise Physiology Laboratory.Participants:Seventy sedentary, healthy older men (n=34) and women (n=36).Intervention:Approximately 23 weeks of ST performed 3 days per week.Measurements:Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid.Results:Systolic BP decreased in C‐allele carriers at the AGT A–20C locus with ST (122±1 to 116±2 mmHg,P<.05), which was significantly greater than the decrease in the A homozygotes (126±1 to 123±1 mmHg,P<.05). At the AGTR1 A1166C locus, diastolic BP decreased to a greater extent in the C‐allele carriers (76±1 to 70±2 mmHg,P<.05) than in the A homozygotes (75±1 to 72±1 mmHg,P<.05).Conclusion:The AGT A–20C and AGTR1 A1166C genotypes may influence resting BP response to ST, such that C‐allele carriers at each of these loci reduce their resting BP in response to ST to a greater extent than A homozygotes.