A Copper-Catalyzed Arylation of Tryptamines for the Direct Synthesis of Aryl Pyrroloindolines.
A Copper-Catalyzed Arylation of Tryptamines for the Direct Synthesis of Aryl Pyrroloindolines.
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DOI：
10.1039/c2sc20914d
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发表时间：
2012-11
期刊：
影响因子：
8.4
通讯作者：
Reisman SE
中科院分区：
文献类型：
--
作者：
Kieffer ME;Chuang KV;Reisman SE
操作简单，铜催化的n -甲基色胺的芳基化提供了直接获得c3 -芳基吡咯啉的途径。吲哚主链和芳基亲电试剂上都能容忍一系列供电子和吸电子取代基。这些反应在环境温度下发生，偶联物的量等摩尔。
An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners.