COVID-19 infection in patients with late-onset Pompe disease.
COVID-19 infection in patients with late-onset Pompe disease.
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DOI：
10.1002/mus.27482
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发表时间：
2022-03
期刊：
影响因子：
3.4
通讯作者：
Mozaffar T
中科院分区：
文献类型：
--
作者：
Avelar J;Wencel M;Chumakova A;Mozaffar T
严重急性呼吸综合征冠状病毒- 2 2019 （SARS - CoV2/COVID - 19）在先前存在呼吸和心血管疾病的个体中通常更为严重。对神经肌肉疾病患者的影响令人担忧，但在很大程度上仍然未知。迟发性庞贝病（LOPD）是一种以进行性骨骼肌和呼吸肌变性为特征的溶酶体贮积性疾病。死亡通常是由呼吸衰竭引起的。我们研究了COVID - 19对这些患者的影响。这是一个由4名LOPD患者感染COVID - 19的病例系列。所有患者均患有轻/中度COVID - 19疾病，不需要住院治疗。其中一人出现神经系统恶化，另外三人的身体能力没有变化，四人的呼吸系统症状保持稳定。在一些LOPD患者中，COVID - 19感染可导致良性病程。然而，LOPD患者仍处于高风险，应接种COVID - 19疫苗并采取预防措施，以避免暴露于COVID - 19感染。
Severe acute respiratory syndrome coronavirus‐2 2019 (SARS‐CoV2/COVID‐19) is frequently more severe in individuals with pre‐existing respiratory and cardiovascular conditions. The impact on patients with neuromuscular disorders is of concern, but remains largely unknown. Late‐onset Pompe disease (LOPD) is a lysosomal‐storage disorder characterized by progressive skeletal and respiratory muscle degeneration. Mortality is typically caused by respiratory failure. We examined the impact of COVID‐19 on these patients. This is a case series of four patients with LOPD who contracted COVID‐19. All patients had a mild/moderate illness from COVID‐19 and did not require hospitalization. Neurological worsening occurred in one, with no change in physical ability in the other three, and respiratory symptoms remained stable in all four. COVID‐19 infection can result in a benign course in some patients with LOPD. However, individuals with LOPD remain at high risk and should receive COVID‐19 vaccinations and exercise precautions to avoid exposure to COVID‐19 infection.
影响因子：
14.5
作者：
Hagemans, MLC;Winkel, LPF;Van der Ploeg, AT
通讯作者：
Van der Ploeg, AT
影响因子：
9.9
作者：
Guidon, Amanda C.;Amato, Anthony A.
通讯作者：
Amato, Anthony A.
影响因子：
158.5
作者：
van der Ploeg, Ans T.;Clemens, Paula R.;Zivkovic, Sasa A.
通讯作者：
Zivkovic, Sasa A.