The role of insulin/IGF-like signaling in C. elegans longevity and aging
The role of insulin/IGF-like signaling in C. elegans longevity and aging
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DOI：
10.1242/dmm.001040
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发表时间：
2010-07-01
影响因子：
4.3
通讯作者：
Murphy, Coleen T.
中科院分区：
文献类型：
--
作者：
Kaletsky, Rachel;Murphy, Coleen T.
衰老的特征是随着时间的推移一般生理衰退。人类衰老的一个标志是各种与年龄有关的疾病的发生，包括神经退行性疾病、心血管疾病和癌症。虽然环境和随机因素无疑有助于随着年龄的增长而增加的疾病发病率，但最近的研究表明，内在的遗传决定因素支配着寿命和总体健康。目前的衰老研究旨在实现“长寿红利”，其中人类寿命的延长伴随着生活质量的提高而实现（Olshansky等人，2007年）。利用模式生物，特别是线虫秀丽隐杆线虫，来描述衰老所涉及的遗传和生化途径，以确定人类治疗干预的策略，已经取得了重大进展。本文讨论了C. elegans为我们理解胰岛素信号和衰老做出了贡献。
Aging is characterized by general physiological decline over time. A hallmark of human senescence is the onset of various age-related afflictions including neurodegeneration, cardiovascular disease and cancer. Although environmental and stochastic factors undoubtedly contribute to the increased incidence of disease with age, recent studies suggest that intrinsic genetic determinants govern both life span and overall health. Current aging research aims at achieving the 'longevity dividend', in which life span extension in humans is accomplished with a concomitant increase in the quality of life (Olshansky et al., 2007). Significant progress has been made using model organisms, especially the nematode worm Caenorhabditis elegans, to delineate the genetic and biochemical pathways involved in aging to identify strategies for therapeutic intervention in humans. In this review, we discuss how C. elegans has contributed to our understanding of insulin signaling and aging.