Tetradecanuclear and Octadecanuclear Gold(I) Sulfido Clusters: Synthesis, Structures, and Luminescent Selective Tracking of Lysosomes in Living Cells
Tetradecanuclear and Octadecanuclear Gold(I) Sulfido Clusters: Synthesis, Structures, and Luminescent Selective Tracking of Lysosomes in Living Cells
复制标题
十四核和十八核金 (I) 硫簇：活细胞中溶酶体的合成、结构和发光选择性追踪
DOI：
10.1021/acs.inorgchem.8b03298
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发表时间：
2019-03-18
影响因子：
4.6
通讯作者：
Lang, Jian-Ping
中科院分区：
文献类型：
--
作者：
Liu, Chun-Yu;Wei, Xue-Rui;Lang, Jian-Ping
膦基金（I）前体[（AuCl）（2）（bdppmapy）]（1; bdppmapy = N，N-双（二苯基膦基甲基）-2-氨基吡啶）与Na 2S以1：1或1：2的摩尔比反应，分别生成一个十四核和一个八核Au（I）硫化物簇[Au，S-6（bdppmapy）5]Cl-2（2）和[Au 18 S8（bdppmapy）6]Cl-2（3）。前者展示了金团簇化学中一种新的结构框架。化合物2和3显示出很强的绿色发光，并被用作优良的成像探针，选择性地照亮活细胞的溶酶体。它们对溶酶体的长期跟踪可达36 h，而在相同条件下用市售Lyso-Tracker Red进行跟踪仅限于3 h。我们的工作证明了构建由特殊的P-N杂化配体支持的新型金（I）硫化物簇的可能性，以及这些簇作为溶酶体的长期选择性示踪剂在生物成像中的潜在应用。
Reactions of the phosphanyl-gold(I) precursor [(AuCl)(2) (bdppmapy)] ( 1; bdppmapy = N,N-bis(diphenylphosphanylmethyl)-2-aminopyridine) with Na2S in a 1:1 or 1:2 molar ratio gave rise to one tetradecanuclear and one octanuclear Au(I) sulfido cluster, [Au,S-6(bdppmapy)5]Cl-2 (2) and [Au18S8(bdppmapy)6]Cl-2 (3), respectively. The former displays a new structural framework in gold cluster chemistry. Compounds 2 and 3 showed strong green luminescence and were employed as excellent imaging probes to selectively light up the lysosomes of living cells. Their long-term tracking of lysosomes can be achieved for up to 36 h, while tracking with commercial Lyso-Tracker Red under the same conditions was limited to 3 h. Our work demonstrated the possibility of constructing novel gold(I) sulfido clusters supported by special P-N hybrid ligands and the potential application of these clusters as long-term selective trackers of lysosomes in bioimaging.