Human recombinant interleukin-1 receptor antagonist blocks bone resorption induced by interleukin-1 beta but not interleukin-1 alpha.
Human recombinant interleukin-1 receptor antagonist blocks bone resorption induced by interleukin-1 beta but not interleukin-1 alpha.
复制标题
人重组白细胞介素 1 受体拮抗剂可阻断白细胞介素 1 β 诱导的骨吸收，但不能阻断白细胞介素 1 α 诱导的骨吸收。
DOI：
10.1007/bf00310162
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发表时间：
1994
影响因子：
4.2
通讯作者：
Faddis,BT
中科院分区：
文献类型：
--
作者：
Chole,RA;Tinling,SP;Faddis,BT
白细胞介素-1 α（IL-1α）和白细胞介素-1 β（IL-1β）在体内和体外都是强有力的骨吸收刺激因子。白细胞介素-1受体拮抗剂（IL-1 ra）可与多种白细胞介素-1受体结合。它不激活受体，并有效地阻断IL-1α和IL-1β的作用。在这项研究中，发现100倍过量的人重组IL-1 ra可阻断IL-1β而非IL-1α对培养小鼠颅骨的骨吸收。这些观察结果可以通过靶骨细胞上IL-1α、IL-1β和rhIL-1 ra受体的不同亲和力来解释。
Both interleukin-1α (IL-1α) and interleukin-1β (IL-1β) are powerful stimulators of bone resorptionin vivoandin vitro. Interleukin-1 receptor antagonist (IL-1ra) binds to many interleukin-1 receptors. It does not activate the receptor and effectively blocks the action of IL-1α and IL-1β. In this study, human recombinant IL-1ra, at 100-fold excess, was found to block bone resorption in cultured mouse calvaria due to IL-1β but not IL-1α. These observations may be explained by differential affinities of receptors for IL-1α, IL-1β and rhIL-1ra on target bone cells.