LIFE-SPAN STUDY OF SPF FISCHER-344 MALE-RATS FED AD-LIBITUM OR RESTRICTED DIETS - LONGEVITY, GROWTH, LEAN BODY-MASS AND DISEASE
LIFE-SPAN STUDY OF SPF FISCHER-344 MALE-RATS FED AD-LIBITUM OR RESTRICTED DIETS - LONGEVITY, GROWTH, LEAN BODY-MASS AND DISEASE
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DOI：
10.1093/geronj/37.2.130
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
LYND, FT
中科院分区：
文献类型：
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作者：
YU, BP;MASORO, EJ;LYND, FT
对屏障维持的SPF Fischer 344大鼠的寿命、病理损伤、生长、瘦体重和肌肉的选定方面进行寿命研究，所述大鼠自由采食（A组）或头自由采食量的60%（R组）。食物限制在延长已经长寿的SPF大鼠的寿命方面与以前在传统设施中饲养的大鼠一样有效。食物限制不仅增加了平均寿命，而且还起到了延长寿命的作用，因为超过60%的R组大鼠比最长寿的A组大鼠寿命更长。A组大鼠的肾脏病变发生在比R组大鼠更早的年龄，并且进展更快。大多数A组大鼠的死亡与严重的肾脏病变相关，而少数R组大鼠在死亡时显示出此类病变。此外，还发现限食可延缓或预防睾丸间质细胞瘤、胆管增生、心肌纤维化和心肌变性。腓肠肌质量下降，在先进的年龄和食物限制延迟这种下降。然而，有趣的是，瘦体重并没有随着年龄的增加而逐渐下降，而是只在疾病晚期开始后才下降。经出版商许可转载。Byung J. Yu，Edward J. Masoro，Ikuo Murata，Helen A.作者：Bertrand，Frederick T. Lynd，SPF Fischer 344雄性大鼠的寿命研究，限脂饮食：寿命、生长、瘦体重和疾病，J.Gerontol.37，130-141（1982）。
A life-span study was carried out on longevity, pathologic lesions, growth, lean body mass, and selected aspects of muscle of barrier-maintained SPF Fischer 344 rats fed eitherad libitum(Group A) or 60% of thead libitumintake (Group R). Food restriction was as effective in prolonging the life of already long-lived SPF rats as previously shown for rats maintained in conventional facilities. Food restriction not only increased the mean length of life but also acted to extend life-span since more than 60% of the Group R rats lived longer than the longest lived Group A rat. Renal lesions occurred at an earlier age in Group A rats than in Group R rats and progressed more rapidly. Death of most Group A rats was associated with severe renal lesions while few Group R rats showed such lesions at death. Food restriction was also found to delay or prevent interstitial cell tumors of the testes, bile duct hyperplasia, myocardial fibrosis and myocardial degeneration. Gastrocnemius muscle mass declined in advanced age and food restriction delayed this decline. Interestingly, however, lean body mass did not progressively decline with increasing age but rather decline occurred only after the onset of the terminal disease process.Copyright (c) The Gerontological Society of America. Reproduced by permission of the publisher.Byung Pal Yu, Edward J. Masoro, Ikuo Murata, Helen A. Bertrand, Frederick T. Lynd, Life Span Study of SPF Fischer 344 Male Rats FedAd Libitumor Restricted Diets: Longevity, Growth, Lean Body Mass and Disease.J. Gerontol.37, 130-141 (1982).