Immunohistochemical localization of Bcl-2 and Bax proteins in in situ and invasive duct breast carcinomas
Immunohistochemical localization of Bcl-2 and Bax proteins in in situ and invasive duct breast carcinomas
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DOI：
10.1007/bf01008011
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Eusebi, V
中科院分区：
文献类型：
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作者：
Kapucuoglu, N;Losi, L;Eusebi, V
Bcl-2和Bax蛋白由一个基因家族编码，这些基因参与维持多细胞生物中细胞增殖速率和程序性细胞死亡之间的平衡。Bax基因通过对抗Bcl-2基因的死亡保护作用而作为细胞死亡的启动子。对58例乳腺导管原位癌（DCIS）、导管浸润癌和浸润性小叶癌（IC）中Bcl-2和Bax蛋白的表达进行了研究。虽然这两种蛋白质在正常和良性上皮中同时表达，但根据肿瘤上皮的分化程度观察到不同的染色模式。在分化良好的DCIS和I级IC中，Bcl-2蛋白染色占优势。II级病变共表达两种蛋白质。低分化DCIS显示Bax蛋白染色模式为主。因此，Bax蛋白表达，特别是在DCIS中，与更具侵袭性的肿瘤相关，而Bcl-2蛋白表达与侵袭性较低的恶性病变相关。
Bcl-2 and Bax proteins are coded by a family of genes that take part in the manteinance of the balance between cell proliferation rate and programmed cell death in multicellular organisms. The Bax gene acts as promoter of cell death by opposing the death protector effect of the Bcl-2 gene. Expression of the Bcl-2 and Bax proteins has been investigated in 58 cases of duct carcinoma in situ (DCIS) and duct invasive and invasive lobular carcinomas (IC) of the breast. While both proteins were expressed at the same time in normal and benign epithelium, different staining patterns were observed according to the degree of differentiation of the neoplastic epithelium. In well-differentiated DCIS and grade I IC there was a predominance of Bcl-2 protein staining. Grade II lesions co-expressed both proteins. Poorly differentiated DCIS displayed a predominantly Bax protein staining pattern. Therefore, it appears that Bax protein expression, especially in DCIS, relates to more aggressive neoplasms while Bcl-2 protein expression is associated with less aggressive malignant lesions.