Psoriasis
Psoriasis
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DOI：
10.1111/j.1346-8138.2010.01037.x
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
W. Boehncke;M. Schön
中科院分区：
文献类型：
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作者：
W. Boehncke;M. Schön
牛皮癣是一种免疫介导的遗传性疾病，表现在皮肤或关节或两者。通常需要一个具有一系列专业知识的多元化临床医生团队来治疗这种疾病。银屑病带来了许多挑战，包括高患病率、慢性化、毁容、残疾和相关合并症。了解免疫功能在银屑病中的作用以及先天免疫系统和适应性免疫系统之间的相互作用有助于控制这种复杂的疾病，这种疾病对患者的影响远远超出了皮肤。在这次研讨会上，我们强调银屑病和相关共病的临床多样性。我们描述了银屑病流行病学、发病机制和遗传学的最新进展，以更好地了解银屑病治疗的当前趋势。我们的主要目标是提高人们对这种多方面疾病的复杂性，最先进的治疗方法的潜力以及对银屑病患者早期诊断和综合管理的必要性的认识。
Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Psoriasis provides many challenges including high prevalence, chronicity, disfiguration, disability, and associated comorbidity. Understanding the role of immune function in psoriasis and the interplay between the innate and adaptive immune system has helped to manage this complex disease, which affects patients far beyond the skin. In this Seminar, we highlight the clinical diversity of psoriasis and associated comorbid diseases. We describe recent developments in psoriasis epidemiology, pathogenesis, and genetics to better understand present trends in psoriasis management. Our key objective is to raise awareness of the complexity of this multifaceted disease, the potential of state-of-the-art therapeutic approaches, and the need for early diagnosis and comprehensive management of patients with psoriasis.