Cancer incidence within a cohort occupationally exposed to asbestos: a study of dose-response relationships
Cancer incidence within a cohort occupationally exposed to asbestos: a study of dose-response relationships
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DOI：
10.1136/oem.2010.059790
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发表时间：
2011-11-01
影响因子：
4.9
通讯作者：
Letourneux, Marc
中科院分区：
文献类型：
--
作者：
Clin, Benedicte;Morlais, Fabrice;Letourneux, Marc
Objectives--我们研究的目的是分析职业性石棉暴露与cancer.Methods风险之间的剂量-反应关系，我们的研究是一项回顾性发病率研究，基于2024例职业性石棉暴露者，在1978年1月1日至2004年12月31日期间进行。采用考克斯模型分析职业石棉暴露（作为时间依赖变量）与癌症风险之间的剂量-反应关系。为了解释潜伏期的影响，我们进行了10年的滞后分析。结果在我们的队列中观察到285例癌症。与石棉暴露相关的胸膜-腹膜间皮瘤、肺癌和结直肠癌的相对危险度，以年龄作为时间依赖变量和性别进行校正，与暴露强度（或平均暴露水平，AEL）相关。癌症的风险，无论解剖部位，并没有增加暴露于asbestosmos.Conclusion的时间，同时确认石棉暴露和胸膜肺和腹膜癌之间的关系，这项研究还表明，石棉暴露和结直肠癌之间的因果关系。
Objectives The aim of our study was to analyse the dose-response relationship between occupational asbestos exposure and risk of cancer.Methods Our study was a retrospective morbidity study based on 2024 subjects occupationally exposed to asbestos, conducted over the period 1 January 1978 to 31 December 2004. Analysis of the dose-response relationship between occupational asbestos exposure, as a time-dependant variable, and risk of cancer was performed using a Cox model. In order to account for the effect of latency, we conducted the analysis with a lag of 10 years.Results 285 cases of cancers were observed in our cohort. The relative risk of pleuro-peritoneal mesothelioma, lung cancer and colorectal cancer associated with asbestos exposure, adjusted for age as a time-dependant variable and for sex, was correlated with exposure intensity (or average exposure level, AEL). The risk of cancer, whatever the anatomical site, did not increase with the duration of exposure to asbestos.Conclusion While confirming the established relationship between asbestos exposure and pleuropulmonary and peritoneal cancers, this study also suggests a causal relationship between asbestos exposure and colorectal cancer.