Silver/hydroxyapatite composite coatings on porous titanium surfaces by sol-gel method.
Silver/hydroxyapatite composite coatings on porous titanium surfaces by sol-gel method.
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DOI：
10.1002/jbm.b.31784
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发表时间：
2011-04
期刊：
影响因子：
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通讯作者：
J. Qu;Xiong Lu;Dan Li;Yonghui Ding;Y. Leng;J. Weng;S. Qu;B. Feng;F. Watari
中科院分区：
文献类型：
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作者：
J. Qu;Xiong Lu;Dan Li;Yonghui Ding;Y. Leng;J. Weng;S. Qu;B. Feng;F. Watari
负载纳米银粒子的羟基磷灰石涂层是赋予羟基磷灰石涂层抗菌性能的一种有吸引力的方法。在多孔Ti基板上生产Ag/HA涂层一直是一项艰巨的工作，因为常用的视线技术无法在多孔Ti的内孔表面沉积均匀的涂层。本研究采用聚合物浸渍法制备了具有高孔隙度和相互连接结构的多孔钛支架。采用溶胶-凝胶法制备了多孔钛基表面均匀的Ag/HA复合涂层。选择乙醇基体系中的Ca(NO(3))(2)·4H(2) O和P(2) O(5)制备溶胶，保证了银在溶胶中的均匀分布，表征表明银颗粒均匀分布在镀层中，无团聚现象。含银膜对大肠杆菌和白弧菌的抑菌率分别为0.8和1.6 wt %，抑菌率达95%。Ag/HA 0.8表面的生物相容性与纯HA表面一样好，在其上培养成骨细胞。结果表明，Ag/HA 0.8在涂层的生物相容性和抗菌性能之间取得了较好的平衡。
Hydroxyapatite (HA) coatings loaded with nanosilver particles is an attractive method to impart the HA coating with antibacterial properties. Producing Ag/HA coatings on porous Ti substrates have been an arduous job since commonly used line-of-sight techniques are not able to deposit uniform coatings on the inner pore surfaces of the porous Ti. In this study, porous Ti scaffolds with high porosity and interconnected structures were prepared by polymer impregnating method. A sol-gel process was used to produce uniform Ag/HA composite coatings on the surfaces of porous Ti substrates. Ca(NO(3) )(2) ·4H(2) O and P(2) O(5) in an ethyl alcohol based system was selected to prepare the sol, which ensured the homogeneous distribution of Ag in the sol. The characterization revealed that silver particles uniformly distributed in the coatings without agglomeration. High antibacterial ratio (>95%), against E. coli and S. albus was expressed by the silver-containing coatings (Ag/HA 0.8 and 1.6 wt %). The biocompatibility of the Ag/HA 0.8 surfaces was as good as that of pure HA surface, as revealed by culturing osteoblasts on them. The results indicated that Ag/HA 0.8 had the good balance between the biocompatibility and antibacterial properties of the coatings.