Sources of Cognitive Exploration: Genetic Variation in the Prefrontal Dopamine System Predicts Openness/Intellect.
Sources of Cognitive Exploration: Genetic Variation in the Prefrontal Dopamine System Predicts Openness/Intellect.
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DOI：
10.1016/j.jrp.2011.04.002
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发表时间：
2011-08-01
影响因子：
3.3
通讯作者：
Grigorenko EL
中科院分区：
文献类型：
--
作者：
Deyoung CG;Cicchetti D;Rogosch FA;Gray JR;Eastman M;Grigorenko EL
开放/智力人格特质反映了想象力、好奇心、洞察力、艺术性和智力的倾向——所有这些特征都涉及认知探索。人们对开放性/智力的生物学基础知之甚少，但这种特征与前额皮质的认知功能有关，而神经递质多巴胺在探索动机中发挥着关键作用。通过检查多巴胺与前额叶多巴胺能系统的核心组成部分的两个基因的关联，支持了多巴胺参与开放性/智力的假设。在两个人口统计不同的样本中（儿童：N = 608；成人：N = 214），多巴胺 D4 受体基因 (DRD4) 和儿茶酚-O-甲基转移酶基因 (COMT) 的变异预测了开放性/智力，这是儿童样本和成人互动中的主要影响。
The personality trait Openness/Intellect reflects the tendency to be imaginative, curious, perceptive, artistic, and intellectual—all characteristics that involve cognitive exploration. Little is known about the biological basis of Openness/Intellect, but the trait has been linked to cognitive functions of prefrontal cortex, and the neurotransmitter dopamine plays a key role in motivation to explore. The hypothesis that dopamine is involved in Openness/Intellect was supported by examining its association with two genes that are central components of the prefrontal dopaminergic system. In two demographically different samples (children: N = 608; adults: N = 214), variation in the dopamine D4 receptor gene (DRD4) and the catechol-O-methyltransferase gene (COMT) predicted Openness/Intellect, as main effects in the child sample and in interaction in adults.