Physical exercise protects muscle from accelerated aging induced by high-salt intake and muscle CG2196 (salt) gene overexpression in Drosophila
Physical exercise protects muscle from accelerated aging induced by high-salt intake and muscle CG2196 (salt) gene overexpression in Drosophila
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DOI：
10.1016/j.fshw.2023.03.003
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发表时间：
2023-11-01
影响因子：
7
通讯作者：
Hou，Wenqi
中科院分区：
文献类型：
--
作者：
Wen，Dengtai;Chen，Yiling;Hou，Wenqi
Aging decreases muscle mass, strength, and functional capacity. High-salt stress seems to promote muscle aging and decrease lifespan. However, exercise delays muscle aging and increases longevity, and it may protect muscle from rapid aging induced by high-salt intake (HSI), but the molecular mechanisms are poorly understood. In this study, the flies were fed a high-salt diet and trained to exercise. Muscle CG2196 (salt) gene anddSir2gene were over-expressed by building mef2-gal4/UAS system. The results showed that both physical exercise and muscledSir2gene overexpression prevented HSI-induced and musclesaltoverexpression-induced accelerated age-related decline of climbing index, climbing endurance, muscle NAD+level, SOD activity level,dSir2expression, anddFOXOexpression, and they also prevented HSI-induced and musclesaltoverexpression-induced accelerated age-related increase in muscle ROS level, MDA level, andsaltgene expression. Physical exercise improved lifespan decrease induced by HSI and musclesaltoverexpression. Therefore, current results indicated that high-salt stress accelerated muscle aging by decreasing muscular NAD+/dSir2/dFOXO pathway activity and increasing oxidative stress. Physical exercise protected muscle from accelerated aging induced by high-salt stress through activating muscle NAD+/dSir2/dFOXO pathway and enhancing muscle oxidation resistance. The combination of exercise and muscledSir2overexpression had the best protective effect on muscle aging and lifespan in flies.
