p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata
p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata
复制标题
来自内生真菌 Floricola striata 的对三联苯衍生物
DOI：
10.1021/acs.jnatprod.6b00197
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发表时间：
2016-09-01
影响因子：
5.1
通讯作者：
Lou, Hong-Xiang
中科院分区：
文献类型：
--
作者：
Li, Wei;Gao, Wei;Lou, Hong-Xiang
Ten new p-terphenyl derivatives, floricolins A-J (1-10), together with six known compounds (11-16), were isolated from the extract of the endolichenic fungus Floricola striata. Chemical structures of these compounds were elucidated using spectroscopic data (HRESIMS and NMR). Among them, 9 and 10 were enantiomeric mixtures, and their configurations were established by single-crystal X-ray diffraction analysis using Cu K alpha radiation. Evaluation of the isolated compounds against Candida albicans revealed that the most active compound, 3 (MIC 8 mu g/mL), exerted fungicidal action by destruction of the cell membrane.
