On How Psychophysical Thresholds are Altered by Unilateral Brain Injury Due to Stroke.
On How Psychophysical Thresholds are Altered by Unilateral Brain Injury Due to Stroke.
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发表时间：
2021
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通讯作者：
Mennemeier M
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作者：
Allen M;Kretzmer T;Jewell G;Murphy H;Thostenson J;Mennemeier M
这项研究考察了与健康受试者相比，中风引起的单侧左右半球病变是否以及如何改变了11个感觉/知觉连续体的绝对阈值和刚刚可察觉的差异阈值。三组受试者分别为单侧右半球病变组(n=21)、单侧左半球病变组(n=13)和年龄匹配的对照组(n=76)。对跨越视觉、触觉、本体感觉、温度和味觉的感觉连续体的感觉检测的绝对阈值和仅明显的差异阈值进行了评估。对于中风受试者，使用减影技术和MRIcro和MRIcroN软件程序进行体积分析。中风受试者还完成了空间忽视、中风严重性和功能独立性的测试。在性别、种族、手优势、年龄或教育构成方面，受试者组之间没有显著差异。除空间忽略外，左右半球病变的受试者在功能、中风严重程度或病变体积的测量上没有显著差异。RHL组知觉连续性受损的比例(16%)高于正常对照组(4%)和LHL组(9%)。如果中风受试者一侧身体阈值受损，他们另一侧阈值受损的可能性要高出约5倍。这一结果在一小部分表现为感觉阈值受损的正常对照组受试者中更为一致，甚至被夸大了(可能性约为8倍)。病变体积与卒中严重程度、感觉阈值损害呈正相关，与功能独立性呈负相关。当受试者在感知和辨别感官体验方面有困难时，他们倾向于在身体的两侧都这样做。单侧右半球中风似乎增加了身体对侧阈值改变的相对频率，尽管他们在两侧都犯了错误。
This study examined whether and how the absolute thresholds and the just noticeable difference thresholds for eleven, sensory/perceptual continua are altered by unilateral left and right hemisphere lesions due to stroke relative to healthy subjects. The three subject groups were those with unilateral right hemisphere lesions (n=21), with unilateral left hemisphere lesions (n=13), and age-matched control subjects (n=76). Absolute thresholds of sensory detection and just noticeable difference thresholds were assessed for perceptual continua spanning the visual, tactile, proprioceptive, thermal, and gustatory sensory modalities. For stroke subjects, brain lesions were analyzed using subtraction techniques and volume analysis with the MRIcro and MRIcroN software programs. Stroke subjects also complete tests for spatial neglect, stroke severity and functional independence. There was no significant difference among subject groups regarding gender, race, hand dominance, age, or educational composition. There was no significant difference between subjects with right and left hemisphere lesions on measures of function, stroke severity, or lesion volume except for those with spatial neglect. The RHL group had a higher percentage of impaired perceptual continua (16%) than both normal controls (4%) and the LHL group (9%). If a stoke subject had an impaired threshold on one side of the body, they were ~5 times more likely to have an impaired threshold on the other side of the body. This result was more consistent and even exaggerated (~8 times more likely) in the small percentage of normal control subjects who demonstrated “impaired” sensory thresholds. Lesion volume was positively correlated with stroke severity and sensory threshold impairment, and it was negatively correlated with functional independence. When subjects, have difficulty detecting and discriminating sensory experiences, they tend to do so on both sides of the body. Unilateral right hemisphere stroke appeared to increase the relative frequency of altered thresholds occurring on the contralesional side of the body even though they made errors on both sides.