An automated exposure system for human inhalation study.
An automated exposure system for human inhalation study.
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用于人体吸入研究的自动暴露系统。
DOI：
10.1080/00039890209602939
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Wang,Peng-Yau
中科院分区：
文献类型：
--
作者：
Lin,Yu-Sheng;Smith,ThomasJ;Wang,Peng-Yau
作者开发了一个基于计算机的暴露系统，用于人体吸入研究，以研究气体的毒理学。该系统使用一组计算机控制的电磁阀，其根据预定的时间表调节吸入气体并收集来自受试者的呼出气体。志愿者的呼吸活动是同时监测与实时仪器，校准的内部和外部标准。常见的空气污染物，1，3-丁二烯，用于系统验证。结果表明，相对于参考标准，误差小于3%，并且阀操作定时的误差可以忽略不计。呼吸监测方法之间的平均差异在10%以内。拟议的系统是一个易于使用的，可靠的设备，用于人体研究，超过130名受试者进行了测试，在同伴研究。
The authors developed a computer-based exposure system for human inhalation research to study the toxicokinetics of gases. The system uses a set of computer-controlled solenoid valves that regulates inhaled gases and collect exhaled breaths from the subject in accordance with a predetermined time schedule. The volunteer's breathing activity is monitored simultaneously with a real-time instrument, calibrated by both internal and external standards. The common air pollutant, 1,3-butadiene, was used for system validation. The results indicated that the errors were less than 3% relative to reference standards, and the error in the timing of the valve operation was negligible. The average difference between breath-monitoring methods was within 10%. The proposed system is an easy-to-use, reliable device for human studies; more than 130 subjects were tested in a companion study.