Resorption of calcified cartilage as seen in Meckel's cartilage of rats
Resorption of calcified cartilage as seen in Meckel's cartilage of rats
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大鼠梅克尔软骨中钙化软骨的吸收
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
C. Asling
中科院分区：
文献类型：
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作者：
I. Savostin‐Asling;C. Asling
在大鼠身上，一部分梅克尔软骨——位于下颌骨内，但靠近杆的吻侧交汇处——没有形成明确的结构。它为研究软骨吸收提供了特别有利的机会。在胎儿第18天，它被建立为透明的软骨条，并且在其侧面开始形成薄的软骨周围骨壳，在接下来的两天内完成包围。第19天，骨内软骨显示软骨细胞肥大，腔隙增大，基质钙化。破骨细胞在骨的外侧打开一个窗口，开始移除钙化的软骨基质。侵蚀前缘迅速扩张，向内侧移动（在软骨肥大和钙化之前），并沿着节段向近端和远端延伸。破软骨细胞（与破骨细胞相同的多核细胞）在侵蚀前沿占主导地位。毛细血管和各种单核细胞紧随其后。骨形成是非常延迟的，除了在最吻侧肢体，因此，与软骨内成骨的情况相反，人们正在检查的是简单形式的钙化软骨吸收。包括软骨外骨壳在内的骨吸收在21天时基本完成，出生时该部位的膜内骨重组正在进行中。
In rats, a portion of Meckel's cartilage — that lying within the mandible but proximal to the rostral convergence of the bars — gives rise to no definitive structures. It offers especially favorable opportunity to study cartilage resorption. By the eighteenth fetal day it is established as a hyaline cartilage bar, and a thin perichondral bone shell starts to form on its lateral aspect, completing encirclement in the next two days. On day 19 cartilage within this bone shows chondrocyte hypertrophy, lacunar enlargement, and matrix calcification. Osteoclasts open a fenestra laterally in the bone and commence removal of calcified cartilage matrix. The erosion front expands rapidly, moving medially (preceded by cartilage hypertrophy and calcification) and extending proximally and distally along the segment. Chondroclasts (multinucleated cells identical with osteoclasts) dominate the erosion front. Capillaries and various mononucleated cells follow. Bone formation is much delayed except in the most rostral extremity, so that, contrary to the situation in endochondral osteogenesis, one is examining calcified cartilage resorption in uncomplicated form. This resorption, including the perichondral bone shell, is virtually complete by day 21, and intramembranous bony reorganization of the site is in progress at birth.