Pulmonary Sporothrix schenckii infection in a HIV positive child
Pulmonary Sporothrix schenckii infection in a HIV positive child
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DOI：
10.1093/tropej/fmi101
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发表时间：
2006-04-01
影响因子：
2
通讯作者：
Colebunders, R
中科院分区：
文献类型：
--
作者：
Callens, SFJ;Kitetele, F;Colebunders, R
申克孢子丝菌是一种普遍存在的真菌，引起皮肤和皮下组织的大多数非危及生命的局部感染，可以用口服抗真菌药物治疗。脑膜、肺和骨关节播散主要发生在免疫抑制的患者。肺孢子菌病很少见，治疗效果很差。播散性孢子虫病的病例最常报告在南美洲和亚洲的患者中，并且越来越多地报告在艾滋病患者中。申克氏菌在撒哈拉以南非洲的分布和致病性尚不清楚。我们报告一例侵袭性肺孢子体病在金沙萨，刚果民主共和国的一个11岁的艾滋病毒感染的男孩，成功地用口服氟康唑治疗。
Sporothrix schenckii is a ubiquitous fungus, causing mostly non life-threatening localized infections of the skin and subcutaneous tissues that can be treated with oral antifungal agents. Meningeal, pulmonary and osteoarticular dissemination occur mainly in immunosuppressed patients. Pulmonary sporothricosis is rare and responds poorly to treatment. Cases of disseminated sporotrichosis have most frequently been reported in patients residing in South America and Asia, and have increasingly been reported in AIDS patients. The distribution and pathogenicity of S. schenckii in Sub-Saharan Africa is not well known. We report a case of invasive pulmonary sporothrichosis in an eleven year old HIV-infected boy in Kinshasa, Democratic Republic of the Congo, successfully treated with oral fluconazole.