Protection of cattle against rinderpest by intranasal immunisation with a dry powder tissue culture vaccine
Protection of cattle against rinderpest by intranasal immunisation with a dry powder tissue culture vaccine
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DOI：
10.1016/s0264-410x(00)00228-0
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发表时间：
2000-11-22
期刊：
影响因子：
5.5
通讯作者：
Donaldson, AI
中科院分区：
文献类型：
--
作者：
Anderson, J;Fishbourne, E;Donaldson, AI
干粉组织培养牛瘟疫苗，每剂含10(2.5)TCID50病毒，滴鼻给牛，可诱导高滴度循环抗体反应，并能抵抗牛瘟强毒株的攻击。将病毒剂量减少到10(1.1)TCID50导致未能引起可检测到的抗体反应和缺乏保护。与传统的针头注射水溶液牛瘟疫苗相比，鼻腔粉末疫苗有几个优点，包括在没有冷链的情况下更稳定，减少疫苗群体中存在的其他微生物制剂的“针头转移”风险，以及更低的成本。(C)2000爱思唯尔科学有限公司。保留所有权利。
Dry powder tissue culture rinderpest vaccine containing 10(2.5) TCID50 of virus per dose administered intranasally to cattle induced high titre circulating antibody responses and protection against challenge with a virulent strain of rinderpest virus. A reduction in the dose of virus to 10(1.1) TCID50 resulted in a failure to elicit detectable antibody responses and a lack of protection. Intranasal powder vaccine offers several advantages over conventional needle-administered aqueous rinderpest vaccine, including greater stability in the absence of a cold chain, reduced risk of 'needle transfer' of other microbial agents present in the vaccinated herd and lower cost. (C) 2000 Elsevier Science Ltd. All rights reserved.