Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin
Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin
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DOI：
10.1111/jgh.12376
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发表时间：
2014-01-01
影响因子：
4.1
通讯作者：
Kawada, Norifumi
中科院分区：
文献类型：
--
作者：
Hai, Hoang;Tamori, Akihiro;Kawada, Norifumi
背景和目的目前尚不清楚哪些因素与慢性丙型肝炎病毒（HCV）感染患者用聚乙二醇干扰素和利巴韦林（RBV）治疗72周的结果相关。方法在66名对聚乙二醇干扰素和RBV治疗72周有晚期病毒应答（LVR）的HCV基因型1患者中，我们检查了决定结果的因素，结果66例LVR患者中有37例（56%）获得了持续病毒应答（SVR）。这37例SVR患者的平均年龄为55岁，而29例复发患者的平均年龄为61岁（P=0.009）。ITPA rs 1127354 CC基因型54例中26例（48%）和CA/AA基因型12例中11例（92%）获得SVR（P=0.006）。在第16、20、24和28周或之后，HCV RNA检测不到的患者的SVR率分别为79%、40%、60%和33%（P=0.014）。最后，治疗44周时，SVR组的血清RBV浓度（2651 ng/mL）显著高于复发组（1989 ng/mL，P=0.002）。相比之下，白细胞介素-28B基因型的比率在两组之间没有差异。多元回归分析显示，年龄
Background and AimIt is not yet clear which factors are associated with the outcome of 72-week treatment with pegylated-interferon and ribavirin (RBV) in patients with chronic hepatitis C virus (HCV) infection.MethodsIn 66 patients with HCV genotype 1 who had a late viral response (LVR) to 72-week treatment of pegylated-interferon and RBV, we examined the factors that determined the outcome, including single nucleotide polymorphisms of interleukin-28B and inosine triphosphatase (ITPA) genes.ResultsThirty seven of 66 (56%) patients with LVR achieved a sustained viral response (SVR). The mean age of these 37 SVR patients was 55, compared with 61 in 29 relapsed patients (P=0.009). Twenty six of 54 (48%) patients with the CC genotype and 11 of 12 (92%) with the CA/AA genotype of ITPA rs1127354 achieved SVR (P=0.006). The SVR rates were 79%, 40%, 60%, and 33% in patients with undetectable HCV RNA on weeks 16, 20, 24, and 28 or later, respectively (P=0.014). Finally, serum RBV concentration at week 44 of treatment was significantly higher in the SVR group (2651ng/mL) than in the relapse group (1989ng/mL, P=0.002). In contrast, the rate of the interleukin-28B genotype was not different between the groups. Multiple regression analysis showed that age