Immune responses to invasive aspergillosis: new understanding and therapeutic opportunities.
Immune responses to invasive aspergillosis: new understanding and therapeutic opportunities.
复制标题
侵袭性曲霉病的免疫反应：新的认识和治疗机会。
DOI：
10.1097/qco.0000000000000381
复制
发表时间：
2017-08
影响因子：
3.9
通讯作者：
Hohl TM
中科院分区：
文献类型：
--
作者：
Hohl TM
Invasive aspergillosis is a worldwide disease that primarily affects immune-compromised patients, agricultural workers with corneal abrasions, individuals with structural lung disease, and patients with primary immune deficiency. The critical function of the immune system is to prevent the germination of airborne conidia into tissue-invasive hyphae. This review covers recent advances that shape our understanding of anti-Aspergillus immunity at the molecular and cellular level. Host defense against conidia and hyphae occurs via distinct molecular mechanisms that involve intracellular and extracellular killing pathways, as well as cooperation between different myeloid cell subsets. The strength and efficacy of the host response is shaped by the tissue microenvironment. In preclinical models of disease, host immune augmentation strategies have yielded benefits, yet translating these insights into therapeutic strategies in humans remains challenging. Although advances in early diagnostic strategies and in antifungal drugs have ameliorated clinical outcomes of invasive aspergillosis, further improvements depend on gaining deeper insight into and translating advances in anti-Aspergillus immunity.
