Orbitofrontal lesions impair use of cue-outcome associations in a devaluation task
Orbitofrontal lesions impair use of cue-outcome associations in a devaluation task
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DOI：
10.1037/0735-7044.119.1.317
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发表时间：
2005-02-01
影响因子：
1.9
通讯作者：
Holland, PC
中科院分区：
文献类型：
--
作者：
Pickens, CL;Saddoris, MP;Holland, PC
眶额皮质（CFC）与使用结果预期来指导行为有关。本研究使用了一个贬值的任务来检查这个功能。老鼠首先接受清淡食物配对，然后是旨在降低食物价值的食物毒素配对。在兴奋性毒性或假OFC损伤后，重新评估对光的反应。假损伤大鼠表现出减少响应光相对于行为控制，已收到的食物和毒素未配对。相反，OFC损伤的大鼠没有表现出这种减少。结合以往的数据（C. L.皮肯斯，M. P. Saddoris，B. Setlow，M.加拉格尔，P. C。Holland，& G. Schoenbaum，2003），这些结果表明，OFC是至关重要的维护信息的当前激励价值的决策者或使用该信息来指导行为。
The orbitofrontal cortex (CFC) has been implicated in the use of outcome expectancies to guide behavior. The present study used a devaluation task to examine this function. Rats first received light-food pairings followed by food-toxin pairings designed to devalue the food. After either excitotoxic or sham OFC lesions, responding to the light was reassessed. Sham-lesioned rats showed reduced responding to the light relative to behavioral controls, which had received food and toxin unpaired. In contrast, OFC-lesioned rats showed no such reductions. Combined with previous data (C. L. Pickens, M. P. Saddoris, B. Setlow, M. Gallagher, P. C. Holland, & G. Schoenbaum, 2003), these results indicate that the OFC is critical for the maintenance of information about the current incentive value of reinforcers or the use of that information to guide behavior.