Adjunctive yoga v. health education for persistent major depression: a randomized controlled trial.
Adjunctive yoga v. health education for persistent major depression: a randomized controlled trial.
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DOI：
10.1017/s0033291717000575
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发表时间：
2017-09
影响因子：
6.9
通讯作者：
Miller IW
中科院分区：
文献类型：
--
作者：
Uebelacker LA;Tremont G;Gillette LT;Epstein-Lubow G;Strong DR;Abrantes AM;Tyrka AR;Tran T;Gaudiano BA;Miller IW
本研究的目的是确定哈他瑜伽是否是一种有效的干预措施，持续抑郁症状的个人，尽管抗抑郁药治疗。我们进行了一项随机对照试验，每周瑜伽课程（n = 63）与健康教育课程（健康生活工作坊，或HLW; n = 59）在抑郁症状加重和抗抑郁药物使用的个体中进行。HLW作为注意力控制组。干预期为10周，3个月和6个月后进行随访评估。主要结局是10周时由盲法评估者评估的抑郁症状严重程度。次要结果包括整个干预和随访期间的抑郁症状、社会和角色功能、一般健康感知、疼痛和身体功能。在第10周，我们没有发现两组之间抑郁症状的统计学显著差异（B=-0.82，SE=0.88，p=0.36）。然而，在整个干预和随访期间，当控制基线时，瑜伽参与者的抑郁水平低于HLW参与者（B =-1.38，SE = 0.57，p = 0.02）。51%的瑜伽参与者在6个月随访时表现出反应（抑郁症状减轻≥ 50%），而HLW参与者为31%（OR = 2.31; p = 0.04）。随着时间的推移，瑜伽参与者表现出明显更好的社会和角色功能以及一般健康感知。虽然我们在干预期结束时没有看到抑郁症状的差异，但瑜伽参与者在整个随访期间表现出更少的抑郁症状。瑜伽的好处可以随着时间的推移而积累。
The objective of this study was to determine whether hatha yoga is an efficacious adjunctive intervention for individuals with continued depressive symptoms despite antidepressant treatment. We conducted a randomized controlled trial of weekly yoga classes (n = 63) vs. health education classes (Healthy Living Workshop, or HLW; n = 59) in individuals with elevated depression symptoms and antidepressant medication use. HLW served as an attention-control group. The intervention period was 10 weeks, with follow-up assessments 3 and 6 months afterwards. The primary outcome was depression symptom severity assessed by blind rater at 10 weeks. Secondary outcomes included depression symptoms over the entire intervention and follow-up periods, social and role functioning, general health perceptions, pain, and physical functioning. At 10 weeks, we did not find a statistically significant difference between groups in depression symptoms (b=−0.82, SE=0.88, p=0.36). However, over the entire intervention and follow-up period, when controlling for baseline, yoga participants showed lower levels of depression than HLW participants (b = −1.38, SE = 0.57, p = 0.02). Fifty-one percent of yoga participants demonstrated a response (≥ 50% reduction in depression symptoms) at 6 month-follow-up, compared to 31% of HLW participants (OR = 2.31; p = 0.04). Yoga participants showed significantly better social and role functioning and general health perceptions over time. Although we did not see a difference in depression symptoms at the end of the intervention period, yoga participants showed fewer depression symptoms over the entire follow-up period. Benefits of yoga may accumulate over time.