Association between recovery of frailty state and the nonparametric rest-activity rhythm patterns in the elderly community-dwellers: A 6-month follow-up study during Covid-19 pandemic
Association between recovery of frailty state and the nonparametric rest-activity rhythm patterns in the elderly community-dwellers: A 6-month follow-up study during Covid-19 pandemic
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DOI：
10.1080/07420528.2022.2136524
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发表时间：
2022-10-29
影响因子：
2.8
通讯作者：
Kodama，Ayuto
中科院分区：
文献类型：
--
作者：
Kume，Yu;Kodama，Ayuto
老年人虚弱的可逆性已被广泛讨论，但虚弱状态的恢复与休息-活动节律(RAR)模式之间的联系仍不清楚。目前这项研究的目的是检验老年社区居民干预后，RAR模式在基线上与脆弱状态变化的预测因子。本研究在新冠肺炎大流行期间，即2020年4月至2022年3月期间进行。参与者是从秋田市或育里洪州市主办的老年人锻炼计划中公开招募的。采用修订的日本版心血管健康研究标准(修订的J-CHS标准)在干预前和干预6个月后评估每个参与者的虚弱状态。为了测量非参数RAR参数，包括每日稳定性(IS)、日内变异性(IV)、相对幅度(RA)和平均体力活动，在平均24小时曲线上，最活跃的10小时跨度(M10)或最不活跃的5小时跨度(L5)，Actiwatch Spectrum Plus设备被戴在每个参与者的非优势手腕上，连续7天。最终样本75人，除资料不完整者外，干预6个月后按虚弱变化分为改良组(n=12)、维持组(n=53)和劣化组(n=910)。多项Logistic回归分析结果显示，干预6个月后，脆弱状态的改善与基线时IS和总夜间睡眠时间低相关，初始时的M10和L5也能预测脆弱状态的恶化。这项跟踪研究的结果为我们提出的建议提供了依据，即干预后老年人RAR模式的改变可能与虚弱状态的恢复或恶化有关。然而，这一潜在的发现需要进一步的纵向调查。
Reversibility of frailty in the elderly has been discussed comprehensively and but association between recovery of frail state and rest-activity rhythm (RAR) patterns remains unclear. The aim of the current study was to examine a predictor of RAR patterns at the baseline against change of frail state after the intervention in the elderly community-dwellers. This study was performed during Covid-19 pandemic, at the period from April in 2020 to March in 2022. Participants were publicly recruited from senior’s exercise program hosted by Akita city or Yurihonjo city. The revised Japanese version of the Cardiovascular Health Study criteria (revised J-CHS criteria) was used to assess frail state in each participant before and after the 6-month intervention. To measure the nonparametric RAR parameters consisting of interdaily stability (IS), intra-daily variability (IV), relative amplitude (RA) and average physical activity for the most active 10-h span (M10) or for the least active 5-h span (L5) over the average 24-h profile, an Actiwatch Spectrum Plus device was worn on each participant’s non-dominant wrist for seven continuous days. The final samples were 75 participants except for persons with uncompleted data, classified into the improved group (n = 12), the maintained group (n = 53) and the deteriorated group (n = 10) according to frail alteration after the six-month intervention. As a result of the multinomial logistic regression analysis with the reference of the maintained group, the improvement of frail state associated with a low value of IS and total night-sleep time at the baseline, and M10 and L5 at the initial time were also able to predict worsening of frail state after the six-months intervention. A result of this follow-up study provides grounds for our proposal that alterations of RAR patterns in the elderly could be observed in association with recovery or worsening of frail state after the intervention. The potential finding, however, warrants further longitudinal investigation.