Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer's Disease.
Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer's Disease.
复制标题
作者：
Jia K;Du H
高龄是阿尔茨海默病 (AD) 等与衰老相关的脑部疾病的最大危险因素。然而，将衰老与 AD 机械联系起来的详细机制仍然难以捉摸。近年来，脑衰老和 AD 的线粒体假说得到了强调。线粒体通透性转变孔（mPTP）是线粒体对线粒体内和细胞内应激的反应。 mPTP 过度激活与衰老和 AD 大脑中的线粒体功能障碍有关。本文综述了mPTP在衰老和AD中的研究最新进展，并试图从mPTP介导的线粒体功能障碍的角度建立脑衰老和AD之间的联系。
Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction.
登录
查看更多内容
影响因子：
5.5
作者：
Azarashvili, Tamara;Krestinina, Olga;Reiser, Georg
通讯作者：
Reiser, Georg
影响因子：
5
作者：
Baines, Christopher P.
通讯作者：
Baines, Christopher P.
DOI：
10.1073/pnas.1401591111
发表时间：
2014-07-22
影响因子：
11.1
作者：
Alavian, Kambiz N.;Beutner, Gisela;Jonas, Elizabeth A.
通讯作者：
Jonas, Elizabeth A.
影响因子：
64.8
作者：
Baines, CP;Kaiser, RA;Molkentin, JD
通讯作者：
Molkentin, JD
影响因子：
4.2
作者：
Amadoro, Giuseppina;Corsetti, Veronica;Calissano, Pietro
通讯作者：
Calissano, Pietro