Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy
Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy
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基于苯丁酸氮芥和肽药物的超分子水凝胶用于癌症联合治疗
DOI：
10.1021/acsami.8b18425
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发表时间：
2019
影响因子：
9.5
通讯作者：
Jianfeng Liu
中科院分区：
文献类型：
--
作者：
Lijun Yang;Congrou Zhang;Chunhua Ren;Jinjian Liu;Yumin Zhang;Jing Wang;Fan Huang;Lei Zhang;Jianfeng Liu
近年来，自组装多肽-药物偶联超分子水凝胶被认为是治疗癌症的有效的自递送药物系统。在此基础上，将小分子药物百菌清(CRB)和多肽药物酪丝妥泰(YSV)同时偶联到自组装肽上，制备了一种新型的基于自组装肽的超分子水凝胶。与游离分子相比，具有纳米纤维结构的水凝胶显示出更好的抗蛋白酶K降解的稳定性和更好的细胞摄取性能。因此，它在体外和体内都表现出更高的抗肿瘤效率，并具有良好的生物相容性。这种生物相容的自给药系统不仅可以显著提高小分子药物的给药效率，而且可以充分协同CRB和YSV的抗肿瘤作用，为肿瘤联合治疗的新策略的设计提供了灵感。
Supramolecular hydrogels of self-assembling peptide–drug conjugates have been considered as effective self-delivery drug systems for cancer therapy in recent years. Here, a novel self-assembling peptide-based supramolecular hydrogel was developed by simultaneously conjugating small-molecule drug chlorambucil (CRB) and peptide drug tyroservatide (YSV) to the self-assembling peptide. The resulting hydrogel with a nanofiber structure showed enhanced stability against proteinase K degradation and an improved cellular uptake performance in comparison with the free molecules. As a consequence, it exhibited enhanced antitumor efficiency both in vitro and in vivo with favorable biocompatibility. This biocompatible self-delivery drug system could not only significantly improve the delivery efficiency of the small-molecule drugs but also adequately synergize the antitumor effect of CRB and YSV, inspiring the design of new strategies of cancer combination therapy.