Possible inhibitory influence of gamma-aminobutyric acid on growth hormone secretion in the rat.
Possible inhibitory influence of gamma-aminobutyric acid on growth hormone secretion in the rat.
复制标题
γ-氨基丁酸对大鼠生长激素分泌的可能抑制作用。
作者：
J. Fiók;Z. Ács;E. Stark
增加内源性γ-氨基丁酸（GABA）的水平与GABA-转氨酶抑制剂（乙醇胺-O-硫酸盐和γ-炔属GABA）治疗大鼠导致GH的血浆水平下降。通过用3-巯基丙酸抑制GABA合成或用荷包牡丹碱阻断GABA受体来降低GABA能活性，可增加血浆GH浓度。GABA的存在是没有影响的基础上，生长抑素抑制或高K+刺激的GH分泌的半规管腺在体外。结果表明，在特定的实验条件下，GABA抑制GH的分泌。
Increasing the levels of endogenous gamma-aminobutyric acid (GABA) by treating rats with GABA-transaminase inhibitors (ethanolamine-O-sulphate and gamma acetylenic GABA) resulted in a decrease in plasma levels of GH. Diminishing GABAergic activity by inhibiting GABA synthesis with 3-mercaptopropionic acid or by blocking GABA receptors with bicuculline increased plasma concentration of GH. The presence of GABA was without effect on the basal, somatostatin-inhibited or high K+-stimulated secretion of GH by hemipituitary glands in vitro. The results suggest that GABA inhibits secretion of GH under the given experimental circumstances.