Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers.
Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers.
复制标题
DOI：
--
复制
发表时间：
2000-05
期刊：
影响因子：
11.2
通讯作者：
J. Fujimoto;H. Sakaguchi;I. Aoki;T. Tamaya
中科院分区：
文献类型：
--
作者：
J. Fujimoto;H. Sakaguchi;I. Aoki;T. Tamaya
子宫癌微血管计数与白细胞介素-8 （IL -8）水平、浸润性巨噬细胞计数与IL-8水平有显著相关性。免疫组化染色显示巨噬细胞IL-8的定位与CD68相似。20例高IL-8 （<1000 pg/mg蛋白）患者预后极差，而其余60例低IL-8 （<1000 pg/mg蛋白）患者24个月生存率为67%。因此，这表明IL-8可能是一种预后指标，作为肿瘤内部和周围巨噬细胞提供的血管生成因子。
There was a significant correlation between microvessel counts and interleukin (IL)-8 levels and between infiltrated macrophage counts and IL-8 levels in uterine cervical cancers. Immunohistochemical staining revealed that the localization of IL-8 was similar to that of CD68 for macrophages. The prognosis of the 20 patients with high IL-8 (>1000 pg/mg protein) in uterine cervical cancers was extremely poor, whereas the 24-month survival rate of the other 60 patients with low IL-8 (<1000 pg/mg protein) was 67%. Therefore, this indicates that IL-8 might be a prognostic indicator as an angiogenic factor supplied from macrophages within and around the tumor.