B-cell activation and development within chronically inflamed synovium in rheumatoid and reactive arthritis.
B-cell activation and development within chronically inflamed synovium in rheumatoid and reactive arthritis.
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DOI：
10.1006/smim.1997.0076
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发表时间：
1997-08-01
影响因子：
7.8
通讯作者：
Kim, H J
中科院分区：
文献类型：
--
作者：
Berek, C;Kim, H J
在自身免疫性疾病中，B细胞通常在受影响的组织中积聚。在类风湿性关节炎或反应性关节炎的患者中，在发炎的滑膜组织中可能会出现类似生发中心的结构。从这些结构中分离出B细胞，并测定其V基因库。大多数滑膜B细胞是长期记忆细胞，因此是慢性炎症反应的一部分。在滑膜中，建立了一个微环境，其允许初始和记忆B细胞的活化以及它们的V基因库的多样化。对浆细胞的分析表明，这些细胞是长寿的，因此在慢性活化下在滑膜组织中积累。
In autoimmune diseases, B cells often accumulate in the affected tissue. In patients with rheumatoid arthritis or reactive arthritis, germinal center-like structures may develop in the inflamed synovial tissue. B cells from these structures were isolated and their V-gene repertoire determined. The majority of synovial B cells are long-term memory cells and thus are part of the chronic inflammatory reaction. In the synovium a micro-environment is built up which allows the activation of naive and memory B cells and the diversification of their V-gene repertoire. The analysis of plasma cells suggests that these cells are long lived and hence accumulate in the synovial tissue under chronic activation.