GROWTH-RESPONSE TO 4-HYDROXY-L-THREONINE OF ESCHERICHIA-COLI MUTANTS BLOCKED IN VITAMIN-B6 BIOSYNTHESIS
GROWTH-RESPONSE TO 4-HYDROXY-L-THREONINE OF ESCHERICHIA-COLI MUTANTS BLOCKED IN VITAMIN-B6 BIOSYNTHESIS
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DOI：
10.1016/0014-5793(93)80005-f
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发表时间：
1993-03-01
期刊：
影响因子：
3.5
通讯作者：
SPENSER, ID
中科院分区：
文献类型：
--
作者：
DREWKE, C;NOTHEIS, C;SPENSER, ID
在吡多醇（维生素B-6）生物合成中被阻断的大肠杆菌突变体（pdx B和pdx C）对4-羟基-L-苏氨酸表现出生长反应。这一观察结果构成了支持4-羟基-L-苏氨酸与维生素B-6的生物合成有关的观点的第一个直接证据。4-羟基-L-苏氨酸的脱羧产物1-氨基丙-2，3-二醇不支持这些突变体的生长。来自氘标记的I-氨基丙-2，3-二醇的氘未掺入吡哆醇中。
Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B-6) showed a growth response to 4-hydroXy-L-threonine. This observation constitutes the first direct evidence in support of the view that 4-hydroxy-L-threonine is implicated in the biosynthesis of vitamin B-6. 1-Aminopropan-2,3-diol, the decarboxylation product of 4-hydroxy-L-threonine, does not support the growth of these mutants. Deuterium from deuterium-labelled I-aminopropan-2,3-diol was not incorporated into pyridoxol.