Structural insights of homotypic interaction domains in the ligand-receptor signal transduction of tumor necrosis factor (TNF).
Structural insights of homotypic interaction domains in the ligand-receptor signal transduction of tumor necrosis factor (TNF).
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DOI：
10.5483/bmbrep.2016.49.3.205
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发表时间：
2016-03
期刊：
影响因子：
3.8
通讯作者：
Jang SB
中科院分区：
文献类型：
--
作者：
Park YH;Jeong MS;Jang SB
肿瘤坏死因子受体（TNFR）超家族的几个成员在TNF配体-受体信号转导中激活死亡诱导信号复合物（DISC）中的caspase-8。在外源性途径中，凋亡信号转导在死亡结构域（DD）超家族中诱导，其由含有80个氨基酸的六螺旋束组成。DD超家族包括大约100个成员，属于四个亚家族：死亡结构域（DD）、半胱天冬酶募集结构域（CARD）、pyrin结构域（PYD）和死亡效应结构域（DED）。这个超家族包含关键的构建模块：通过这些模块，通过同型相互作用形成多聚体复合物。此外，每个DD结合事件都是排他地发生的。DD超家族调节细胞死亡和存活之间的平衡。在这项研究中，DD超家族成员的结构，功能和独特的功能进行了比较，他们的复合物。通过阐明DD超家族成员的结构见解，我们研究DD结构域的相互作用机制，这些结构域参与TNF配体-受体信号传导。这些DD超家族成员在开发更特异的癌症治疗方法中发挥着关键作用。[BMB报告2016; 49（3）：159-166]
Several members of tumor necrosis factor receptor (TNFR) superfamily that these members activate caspase-8 from death-inducing signaling complex (DISC) in TNF ligand-receptor signal transduction have been identified. In the extrinsic pathway, apoptotic signal transduction is induced in death domain (DD) superfamily; it consists of a hexahelical bundle that contains 80 amino acids. The DD superfamily includes about 100 members that belong to four subfamilies: death domain (DD), caspase recruitment domain (CARD), pyrin domain (PYD), and death effector domain (DED). This superfamily contains key building blocks: with these blocks, multimeric complexes are formed through homotypic interactions. Furthermore, each DD-binding event occurs exclusively. The DD superfamily regulates the balance between death and survival of cells. In this study, the structures, functions, and unique features of DD superfamily members are compared with their complexes. By elucidating structural insights of DD superfamily members, we investigate the interaction mechanisms of DD domains; these domains are involved in TNF ligand-receptor signaling. These DD superfamily members play a pivotal role in the development of more specific treatments of cancer. [BMB Reports 2016; 49(3): 159-166]