Apply pressure-strain loop to quantify myocardial work in pulmonary hypertension: A prospective cohort study.
Apply pressure-strain loop to quantify myocardial work in pulmonary hypertension: A prospective cohort study.
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DOI：
10.3389/fcvm.2022.1022987
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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压力-应变环(PSL)是一种新的定量心脑血管疾病心肌作功的方法。目的：探讨PSL心肌做功参数对评价肺动脉高压患者心功能及临床预后的价值。共有52名PH患者和27名健康对照参加了这项前瞻性研究。用超声心动图测定的PSL计算左、右室的整体做功指数(GWI)。整体构造性功(GCW)包括收缩期缩短期和等容舒张期延长期心肌功的总和。整体浪费功(GWW)包括收缩时延长和等容收缩时缩短时所做的心肌功的总和。全球工作效率定义为GCW/(GCW+GWW)。左、右肺重量均显著高于对照组(P均<0.001)。患者组的LVGWE、LVGWI、LVGCW和RVGWE均低于对照组(P均<0.01)。心肌作功参数与临床和其他常规超声心动图评估有很好的相关性(均P<；0.05)。二元Logistic回归分析显示，RVGWE与肺动脉收缩压联合预测预后最好(OR=0.803，P=0.002；OR=1.052，P=0.015)。受试者工作特征曲线显示RVGWE和ePASP联合预测不良事件的敏感性为100%，特异性为76.3%(Auc=0.910，P<；0.001)。由PSL得出的心肌做功参数是心功能的新兴标志物。RVGWE和ePASP联合检测是预测PH患者临床预后的有用指标。
Pressure-strain loop (PSL) is a novel method to quantify myocardial work in many cardiovascular diseases. To investigate the value of myocardial work parameters derived from PSL for evaluating cardiac function and clinical prognosis in patients with pulmonary hypertension (PH). A total of 52 patients with PH and 27 healthy controls were enrolled in this prospective study. PSLs determined by echocardiography were used to calculate global work index (GWI) of left ventricle (LV) and right ventricle (RV). Global constructive work (GCW) comprised the sum of myocardial work performed during shortening in systole and during lengthening in isovolumic relaxation. Global wasted work (GWW) comprised the sum of myocardial work performed during lengthening in systole and during shortening in isovolumic relaxation. Global work efficiency (GWE) was defined as GCW/(GCW + GWW). LVGWW, RVGWI, RVGCW and RVGWW were significantly higher in patients than controls (all P < 0.001). LVGWE, LVGWI, LVGCW, and RVGWE were lower in patients than controls (all P < 0.01). Myocardial work parameters correlated well with clinical and other conventional echocardiographic assessments (all P < 0.05). In binary logistic regression analysis, the combination of RVGWE and estimation of pulmonary arterial systolic pressure (ePASP) was the best model to predict clinical outcomes (OR = 0.803, P = 0.002 and OR = 1.052, P = 0.015, respectively). Receiver operating characteristic curv demonstrated the combination of RVGWE and ePASP was the best predictor of adverse events with 100% sensitivity and 76.3% specificity (AUC = 0.910, P < 0.001). Myocardial work parameters derived from PSL are emerging markers of cardiac function. And the combination of RVGWE and ePASP is a useful predictor of clinical outcome in PH patients.
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影响因子：
9.6
作者：
Barst, Robyn J.;Chung, Lorinda;McGoon, Michael D.
通讯作者：
McGoon, Michael D.
DOI：
10.1016/j.echo.2017.10.009
发表时间：
2018-02-01
影响因子：
6.5
作者：
Galli, Elena;Leclercq, Christophe;Donal, Erwan
通讯作者：
Donal, Erwan
影响因子：
9.7
作者：
Hardegree, Evan L.;Sachdev, Arun;Kane, Garvan C.
通讯作者：
Kane, Garvan C.
影响因子：
6.2
作者：
Galli, Elena;Leclercq, Christophe;Donal, Erwan
通讯作者：
Donal, Erwan
影响因子：
24.3
作者：
Nickel, N.;Golpon, H.;Hoeper, M. M.
通讯作者：
Hoeper, M. M.