Polyclonal origin of colonic adenomas in an XO/XY patient with FAP
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP
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DOI：
10.1126/science.272.5265.1187
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发表时间：
1996-05-24
期刊：
影响因子：
56.9
通讯作者：
Wright, NA
中科院分区：
文献类型：
--
作者：
Novelli, MR;Williamson, JA;Wright, NA
人们普遍认为，肿瘤是由单个细胞及其后代中的一个或一系列突变引起的单克隆性起源。对1例家族性腺瘤性息肉病(FAP)的XO/XY嵌合体个体的结肠腺瘤和未受累的肠黏膜进行了Y染色体探针原位杂交。在这个病例中，小肠和大肠的隐窝是克隆性的，但至少76%的微腺瘤起源于多克隆性。
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.