Multiscale Stochastic Reaction-Diffusion Modeling: Application to Actin Dynamics in Filopodia
Multiscale Stochastic Reaction-Diffusion Modeling: Application to Actin Dynamics in Filopodia
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DOI：
10.1007/s11538-013-9844-3
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发表时间：
2014-04-01
影响因子：
3.5
通讯作者：
Papoian, Garegin A.
中科院分区：
文献类型：
--
作者：
Erban, Radek;Flegg, Mark B.;Papoian, Garegin A.
研究了丝状伪足中肌动蛋白动力学的两个多尺度（混合）随机反应扩散模型。这两种混合算法结合了联合收割机基于分区和基于分子的随机反应扩散模型。第一个混合模型是基于先前在文献中开发的模型。第二个混合模型是基于最近开发的两个政权的方法（TRM）的应用程序的完全基于分子的模型，这也是本文开发的。混合模型的结果进行了比较与基于分子的模型的结果。结果表明，这两种方法给出了可比的结果，虽然TRM模型更好地同意定量与基于分子的模型。
Two multiscale (hybrid) stochastic reaction-diffusion models of actin dynamics in a filopodium are investigated. Both hybrid algorithms combine compartment-based and molecular-based stochastic reaction-diffusion models. The first hybrid model is based on the models previously developed in the literature. The second hybrid model is based on the application of a recently developed two-regime method (TRM) to a fully molecular-based model, which is also developed in this paper. The results of hybrid models are compared with the results of the molecular-based model. It is shown that both approaches give comparable results, although the TRM model better agrees quantitatively with the molecular-based model.