Physiological roles of the pantothenate kinases.
Physiological roles of the pantothenate kinases.
复制标题
泛酸激酶的生理作用。
DOI：
10.1042/bst20140096
复制
发表时间：
2014-08
影响因子：
3.9
通讯作者：
Jackowski S
中科院分区：
文献类型：
--
作者：
Dansie LE;Reeves S;Miller K;Zano SP;Frank M;Pate C;Wang J;Jackowski S
CoA（辅酶A）是一种重要的辅助因子，参与许多代谢过程。辅酶a是在五个生物合成反应中由泛酸盐产生的。辅酶a生物合成途径受PanKs（泛酸激酶）调控，哺乳动物中有四种活性异构体表达。通过在小鼠中系统地缺失PanKs基因，揭示了PanKs的关键生理功能。
CoA (coenzyme A) is an essential cofactor that is involved in many metabolic processes. CoA is derived from pantothenate in five biosynthetic reactions. The CoA biosynthetic pathway is regulated by PanKs (pantothenate kinases) and four active isoforms are expressed in mammals. The critical physiological functions of the PanKs are revealed by systematic deletion of the Pank genes in mice.