Mechanisms of iron import in anthrax
Mechanisms of iron import in anthrax
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DOI：
10.1007/s10534-011-9413-x
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发表时间：
2011-06-01
期刊：
影响因子：
3.5
通讯作者：
Maresso, Anthony William
中科院分区：
文献类型：
--
作者：
Honsa, Erin Sarah;Maresso, Anthony William
在感染过程中，细菌病原体必须从宿主那里获得铁才能生存。然而，游离铁被隔离在宿主蛋白质中，这对铁依赖性细菌复制构成了障碍。作为回应，病原体已经发展出在感染期间从宿主获得铁的机制。有趣的是，铁池的很大一部分被螯合在血红素中，血红素进一步与宿主蛋白质如血红蛋白结合。大量的血红素铁使血红蛋白成为感染期间靶向铁摄取的理想分子。虽然血红素获取的研究在革兰氏阴性细菌中得到了很好的代表，但革兰氏阳性细菌中血红素摄取的系统和机制只是最近才被研究。炭疽芽孢杆菌是炭疽病的病原体，由于其多方面的生命周期包括细胞内和细胞外阶段以及感染后巨大的复制潜力，因此是研究铁获得过程的极好模式生物。这篇综述提供了对B的当前知识的深入描述。炭疽铁收购和应用这些研究结果如何致病革兰氏阳性菌在感染过程中运输这一关键的营养素的一般理解。
During an infection, bacterial pathogens must acquire iron from the host to survive. However, free iron is sequestered in host proteins, which presents a barrier to iron-dependent bacterial replication. In response, pathogens have developed mechanisms to acquire iron from the host during infection. Interestingly, a significant portion of the iron pool is sequestered within heme, which is further bound to host proteins such as hemoglobin. The copious amount of heme-iron makes hemoglobin an ideal molecule for targeted iron uptake during infection. While the study of heme acquisition is well represented in Gram-negative bacteria, the systems and mechanism of heme uptake in Gram-positive bacteria has only recently been investigated. Bacillus anthracis, the causative agent of anthrax disease, represents an excellent model organism to study iron acquisition processes owing to a multifaceted lifecycle consisting of intra- and extracellular phases and a tremendous replicative potential upon infection. This review provides an in depth description of the current knowledge of B. anthracis iron acquisition and applies these findings to a general understanding of how pathogenic Gram-positive bacteria transport this critical nutrient during infection.