Distribution and density of substance P receptors in the feline gastrointestinal tract using autoradiography.
Distribution and density of substance P receptors in the feline gastrointestinal tract using autoradiography.
复制标题
使用放射自显影术观察猫胃肠道中 P 物质受体的分布和密度。
DOI：
10.1016/0016-5085(91)90655-5
复制
发表时间：
1991
期刊：
影响因子：
29.4
通讯作者：
Ouyang,A
中科院分区：
文献类型：
--
作者：
Rothstein,RD;Johnson,E;Ouyang,A
Autoradiography was used to localize and quantify substance P receptors in the feline gastrointestinal tract. The specific binding of125I-Bolton Hunter substance P was determined in the esophagus, lower esophageal sphincter, antrum, pylorus, duodenum, jejunum, ileum, ileocecal sphincter, and colon. Competitive binding studies indicated that substance P binding sites or NK-1 receptor sites were demonstrated. The concentration of NK-1 receptors was greatest in the distal half of the gastrointestinal tract, with the highest concentrations in the proximal colon. The circular muscle layer contained the greatest amount of substance P binding. The location and density of binding sites for substance P may be important in understanding the relative importance of both the pharmacological responses to this neuropeptide and the immunohistochemical evidence of the peptide at different sites in the intestine.
