In-vivo assessment of tissue metabolite levels using 1H MRS and the Electric REference To access In vivo Concentrations (ERETIC) method
In-vivo assessment of tissue metabolite levels using 1H MRS and the Electric REference To access In vivo Concentrations (ERETIC) method
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DOI：
10.1002/nbm.1476
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发表时间：
2010-05-01
影响因子：
2.9
通讯作者：
Boesiger, P.
中科院分区：
文献类型：
--
作者：
Heinzer-Schweizer, S.;De Zanche, N.;Boesiger, P.
使用电参考获取体内浓度（ERETIC）方法获得了（1）H磁共振波谱中代谢物浓度的定量值，其中在光谱采集期间注入合成参考信号。该方法已得到改进，能够定量体内代谢物浓度。光学信号传输用于消除由于电缆和高介电人体组织的位置变化而导致的ERETIC信号耦合到接收器线圈的随机波动。在体外对信号的稳定性和可靠性进行了测试，达到了平均误差为2.83%的稳定性。证明了在可变负载条件下信号的缩放，并使用发射/接收线圈在3 T Philips系统上采集了大脑的体内测量值。定量脑水和代谢物浓度值与文献中的值吻合良好。版权所有（C）2010约翰威利父子有限公司
Quantitative values of metabolite concentrations in (1)H magnetic resonance spectroscopy have been obtained using the Electric REference To access In vivo Concentrations (ERETIC) method, whereby a synthetic reference signal is injected during the acquisition of spectra. The method has been improved to enable quantification of metabolite concentrations in vivo. Optical signal transmission was used to eliminate random fluctuations in ERETIC signal coupling to the receiver coil due to changes in position of cables and highly dielectric human tissue. Stability and reliability of the signal were tested in vitro, achieving stability with a mean error of 2.83%. Scaling of the signal in variable loading conditions was demonstrated and in-vivo measurements of brain were acquired on a 3T Philips system using a transmit/receive coil. The quantitative brain water and metabolite concentration values are in good agreement with those in the literature. Copyright (C) 2010 John Wiley & Sons, Ltd.