Increased intestinal permeability precedes clinical onset of type 1 diabetes
Increased intestinal permeability precedes clinical onset of type 1 diabetes
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DOI：
10.1007/s00125-006-0465-3
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发表时间：
2006-12-01
期刊：
影响因子：
8.2
通讯作者：
Paroni, R.
中科院分区：
文献类型：
--
作者：
Bosi, E.;Molteni, L.;Paroni, R.
最近的观察表明，人类1型糖尿病的亚临床肠道异常。这些是否与发病过程有关或继发于糖尿病仍有待澄清。本研究的目的是通过检查1型糖尿病不同阶段受试者的肠道对糖的渗透性来研究这个问题：临床前、新发和长期确立的疾病。81例胰岛自身免疫受试者通过乳果糖-甘露醇试验研究了18例临床前、28例新发和35例长期1型糖尿病患者和40例健康对照受试者，包括口服两种糖和测量它们的尿排泄。所有胰岛自身免疫受试者组显示肠通透性增加（p
Recent observations have shown subclinical intestinal abnormalities in human type 1 diabetes. Whether these are related to the pathogenetic process or secondary to the diabetes remains to be clarified. The aim of this study was to investigate this issue by examining intestinal permeability to sugars in subjects at different stages of type 1 diabetes: preclinical, new-onset and long-term established disease.Eighty-one subjects with islet autoimmunity (18 preclinical, 28 new-onset and 35 long-term type 1 diabetes) and 40 healthy control subjects were investigated by a lactulose-mannitol test, consisting of oral administration of the two sugars and measurement of their urinary excretion.All groups of subjects with islet autoimmunity showed an increase in intestinal permeability (p