The Short-Form Leeds Dyspepsia Questionnaire validation study
The Short-Form Leeds Dyspepsia Questionnaire validation study
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DOI：
10.1111/j.1365-2036.2006.03233.x
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发表时间：
2007-02-15
影响因子：
7.6
通讯作者：
Moayyedi, P.
中科院分区：
文献类型：
--
作者：
Fraser, A.;Delaney, B. C.;Moayyedi, P.
背景在消化不良的临床试验中，症状评估应该是主要的结局指标。这需要一个可靠的，有效的和响应的问卷，测量消化不良的频率和严重程度。利兹消化不良问卷满足这些特征，但很长，并且不是为自我完成而设计的，因此开发了一个较短的问卷（简式利兹消化不良问卷）。目的评估该问卷的可接受性、可解释性、内部一致性、可靠性，短时间内的有效性和响应性，表利兹消化不良问卷在初级和二级保健。方法未选择的初级和二级保健患者完成了简短的形式利兹消化不良问卷。2天后评估重测信度。通过与全科医生的诊断进行比较来衡量有效性。采用敏感性分析和逻辑回归确定最有效的评分系统。反应前和治疗后内镜证实diseases.Results的简短形式利兹消化不良问卷进行了测定，以388初级保健和204二级保健患者。重测信度的Pearson系数为0.93。简易利兹消化不良问卷的敏感性为77%，特异性为75%。结论简易利兹消化不良问卷是一种可靠、有效、反应灵敏的自我完成的消化不良症状发生频率和严重程度的测量工具，比利兹消化不良问卷更短、更方便。
Background Assessment of symptoms should be the primary outcome measure in dyspepsia clinical trials. This requires a reliable, valid and responsive questionnaire that measures the frequency and severity of dyspepsia. The Leeds Dyspepsia Questionnaire fulfils these characteristics, but is long and was not designed for self-completion, so a shorter questionnaire was developed (the Short-Form Leeds Dyspepsia Questionnaire).Aim To assess the acceptability, interpretability, internal consistency, reliability, validity and responsiveness of the Short-Form Leeds Dyspepsia Questionnaire in primary and secondary care.Methods Unselected primary and secondary care patients completed the Short-Form Leeds Dyspepsia Questionnaire. Test-retest reliability was assessed after 2 days. Validity was measured by comparison with general practitioners' diagnosis. Sensitivity analysis and logistic regression were employed to determine the most valid scoring system. Responsiveness was determined before and after treatment for endoscopically proven disease.Results The Short-Form Leeds Dyspepsia Questionnaire was administered to 388 primary care and 204 secondary care patients. The Pearson coefficient for test-retest reliability was 0.93. The Short-Form Leeds Dyspepsia Questionnaire had a sensitivity of 77% and a specificity of 75%. A highly significant response to change was observed (P < 0.005).Conclusions The Short-Form Leeds Dyspepsia Questionnaire is a reliable, valid and responsive self-completed outcome measure for quantifying the frequency and severity of dyspepsia symptoms, which is shorter and more convenient than the Leeds Dyspepsia Questionnaire.